Unravelling the impact of Heparan Sulfate profiles in Receptor Tyrosine Kinase activation using gastric cancer as model
Changes in cellular glycosylation patterns have emerged as central feature of cancer progression. Heparan sulfate proteoglycans (HSPGs) are important cellular glycoconjugates that play a critical role in maintaining cellular homeostasis, through the interactions between glycosaminoglycan (GAG) chains and a myriad of biologically relevant ligands. In cancer, particularly in gastric carcinomas, heparan sulfate (HS) glycan chains, and their structural modifications have been implicated in diseas...
