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Increased Susceptibility to Mycobacterium avium in Hemochromatosis Protein HFE-Deficient Mice
Mycobacterium avium is an opportunistic infectious agent in immunocompromised patients, living inside macrophage phagosomes. As for other mycobacterial species, iron availability is a critical factor for M. avium survival and multiplication. Indeed, an association between host secondary iron overload ...
Heme Catabolism by Heme Oxygenase-1 Confers Host Resistance to Mycobacterium Infection
Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of HO-1 expression in macrophages (M...