Expression of let-7b, miR-21 and miR-301a in HPV-induced carcinogenesis and cancer cachexia: studies in K14-HPV16 transgenic mice

Os efeitos da Trazodona na cognição humana: uma revisão sistemática

Trazodone is a widely used antidepressant, also useful in the control of agitation and insomnia in Alzheimer's disease. It is now recognized a new mechanism of action for trazodone, based on its effect on the Unfolded Protein Response (UPR) pathway, restoring protein translation and slowing neurodegenerative progression in mice. These mechanisms may be seen as promising in dementia modifying treatment. To explore the effects of trazodone on human cognition and search for clinical evidence of...

Análise de causas de problemas que afetam a qualidade de dados hospitalares baseados em Grupos de Diagnósticos Homogéneos: revisão sistemática e diagrama Ishikawa

Introduction: Administrative hospital databases built around Diagnosis Related Group (DRG) represent an important tool for hospital financing in several health systems and are also an important data source for clinical, epidemiological and health services research. Therefore, the data quality of such databases is of utmost importance. This paper aims to present a systematic review of root causes of data quality problems affecting DRG-based hospital data, creating a catalogue of potential issu...

Optic Neuropathy Diagnosis in the Emergency Room - Retrospective Observational Study of the last 18 years

Introduction: Optic neuropathies (ON), a broad spectrum of disorders of the optic nerve, are a frequent cause of visual loss, presenting either in isolation or with associated neurological or systemic disorders. They are often first evaluated in the Emergency Room (ER) and have a fast disease course, making the initial approach imperative to diagnose the etiology and begin appropriate treatment. We aim to describe ER demographic data and clinical characteristics as well as the performed imagi...