Cardiotoxicity associated with cancer therapy: Pathophysiology and prevention strategies

Cardiotoxicity is one of the most significant adverse effects of cancer treatment, and is responsible for considerable morbidity and mortality. Among the effects of chemotherapeutic agents on the cardiovascular system, the most frequent and serious is heart failure with ventricular systolic dysfunction. Other toxic effects include hypertension, thromboembolic disease, pericardial disease, arrhythmias and myocardial ischemia. For several decades, cancer therapy-induced cardiomyopathy was almos...

Gold-Mushroom Microelectrode Arrays and the Quest for Intracellular-Like Recordings: Perspectives and Outlooks

The ongoing search to decode the brain communication system has propelled major advancements in bioelectronics research. From these, planar microelectrode arrays (MEAs) offer the possibility to record neuronal signals for extremely long periods of time and to probe fundamental principles of learning and adaptation. Unfortunately, MEAs have low neuronal coupling and are thus insensitive to sub-threshold neuronal signals such as post-synaptic responses. To surpass this major limitation, a novel...

Patterns of street food purchase in cities from Central Asia (vol 9, 925771, 2022) [correction]

In the published article, there was an error in Figure 5 as published. The legend for the red bars was Industrial only and the legend for the green bars was Homemade and industrial.However, these legends weremistakenly switched. As such, the correct legend for the red bars is Homemade and industrial and the correct legend for the green bars is Industrial only. The corrected Figure 5 and its caption appear below. The authors apologize for this error and state that this does not change the scie...

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDRI gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer therapy. For several decades, P-gp inhibition has drawn many significant research efforts in an attempt to overcome this phenomenon. However, P-gp is also constitutively expressed in normal human epithelial tissues and, due to its broad substrate specificity, to its cellular polarized expression in many excretory and barrier tissues, and...