DSpace Community:
https://hdl.handle.net/10216/1879
2024-03-19T13:47:23ZAtendimento no Serviço de Urgência e (Re) Internamentos hospitalares no período de doze meses após o primeiro acidente vascular cerebral num estudo de base populacional - "Tendência na incidência e prognóstico dos acidentes neurológicos - o segundo estudo de base populacional no norte de Portugal - ACIN2
https://hdl.handle.net/10216/153085
Title: Atendimento no Serviço de Urgência e (Re) Internamentos hospitalares no período de doze meses após o primeiro acidente vascular cerebral num estudo de base populacional - "Tendência na incidência e prognóstico dos acidentes neurológicos - o segundo estudo de base populacional no norte de Portugal - ACIN22023-10-10T00:00:00ZVida e Obra de Doutor Tiago Henriques Coelho
https://hdl.handle.net/10216/143731
Title: Vida e Obra de Doutor Tiago Henriques Coelho
Abstract: Tiago Henriques Coelho (1977-2017), MD, PhD, was a professor, physician and researcher at Porto Medical School, Porto University. He started his degree in that very institution in the year of 1995, which has concluded in f 2001. In 2008, he concluded his PhD in Medicine.
Throughout his career, he managed to embrace the two sides of the profession: both teaching and research. On the research field, it is relevant to highlight areas such as physiology, mostly cardiovascular, and pediatric surgery, on which he was a pioneer on neonatal surgery and treating sacrococcygeal pilonidal disease and Pectus Excavatum.
He was also an active member of the Director Council from 2014 to 2017, under the director Professor Maria Amélia Ferreira.
He's also notable for his crucial role as the main agent of development and growth of the Colégio Casa Mãe, Baltar, Paredes, in which he was Executive Director.
During this brief lifetime, he reenforced his professional and personal merits, which are still today celebrated by his peers, family members and friends.
Description: Tiago Henriques Coelho (1977-2017) foi professor, médico e investigador da Faculdade de Medicina da Universidade do Porto. Iniciou o curso de Medicina nesta Faculdade, em 1995, que concluiu em 2001. Realizou provas de Doutoramento em Medicina, em 2008.
O seu percurso passou pelo Ensino e pela Investigação das áreas científicas a que se dedicou na carreira profissional, tais como a Fisiologia, mais especificamente a área cardiovascular e a Cirurgia Pediátrica, sendo pioneiro na cirurgia neonatal e na cirurgia de tratamento da doença pilonidal sacrococcígea e da correção do Pectus Excavatum.
Integrou o Conselho Diretivo da Faculdade de Medicina da Universidade do Porto de 2014 a 2017, no tempo da Diretora da instituição a Doutora Maria Amélia Ferreira.
Teve papel preponderante naquilo que foi a evolução e o crescimento do Colégio Casa Mãe de Baltar, Paredes, onde veio a exercer funções de Diretor Executivo.
No seu escasso tempo de vida soube evidenciar o seu mérito profissional e os seus valores pessoais, facto reconhecido pelos seus pares, familiares e amigos.2022-09-05T00:00:00ZGeneration of ex-vivo 3D organoid culture from surgically-derived tissue of paediatric brain tumours
https://hdl.handle.net/10216/157185
Title: Generation of ex-vivo 3D organoid culture from surgically-derived tissue of paediatric brain tumours2023-11-07T00:00:00ZO Papel da Educação Clínica na Formação de Fisioterapeutas: o processo de ensino/aprendizagem
https://hdl.handle.net/10216/123757
Title: O Papel da Educação Clínica na Formação de Fisioterapeutas: o processo de ensino/aprendizagem2019-11-12T00:00:00ZRecruitment and loading of Dynein-2 into cilia to ensure signaling functions
https://hdl.handle.net/10216/157247
Title: Recruitment and loading of Dynein-2 into cilia to ensure signaling functions2023-10-26T00:00:00ZDegeneração do Disco Intervertebral: Terapia Biológica para a Dor Lombar
https://hdl.handle.net/10216/152752
Title: Degeneração do Disco Intervertebral: Terapia Biológica para a Dor Lombar2023-09-19T00:00:00ZA análise sobre o processo e os resultados a partir da visão dos amigos críticos
https://hdl.handle.net/10216/157638
Title: A análise sobre o processo e os resultados a partir da visão dos amigos críticos2023-01-01T00:00:00ZImpact of Somatic Loss of CDH1 Locus and/or 16q arm in Breast Cancer Progression
https://hdl.handle.net/10216/157141
Title: Impact of Somatic Loss of CDH1 Locus and/or 16q arm in Breast Cancer Progression
Abstract: Breast cancer is the most incident and the fifth most mortal cancer worldwide, being the deadliest cancer in females [1]. Current knowledge has highlighted the expression of hormone receptors (estrogen and progesterone) and HER2 as important drivers of clinical intervention and patient care [2].
Additionally, different molecular signatures have been identified in breast cancer with potential prognostic and therapeutic value [3-6], but none has been brought into clinical practice so far.
The 16q loss is one of the most studied chromosomal abnormalities and the second most frequent in breast cancer [7-11], just after 1q gain [12,13]. However, its biological impact and relationship with clinical features have not yet been characterized.
CDH1, encoding the E-cadherin protein, is a well-known tumor suppressor gene located at the 16q chromosome arm, with a proven role in gastric and breast carcinogenesis [14, 15]. While CDH1 complete loss of function (homozygous inactivation) is considered the trigger for the initiation of lobular breast carcinoma [16] and diffuse type gastric cancer [14, 17] partial (heterozygous) or temporary loss of E-cadherin expression is thought to occur during progression of other histological types of gastric and breast cancer [14,18-22].
CDH1 loss of heterozygosity (LOH) has been associated with poor prognosis in intestinal gastric cancer and with lymph node metastasis in sporadic and hereditary diffuse gastric cancer [14, 23]. In breast cancer, loss of 16q chromosome arm occurs in around 30% of the cases [11], and there is an association with good prognosis, since this group is normally characterized by a Luminal A PAM50 subtype [3, 24]. Our purpose is to fine-map deletions in the 16q chromosome arm in a large series of breast cancers from the METABRIC project, and associate the level of CDH1 loss (homozygous or heterozygous) to patients' clinic-pathological features and prognosis (to be performed in Cambridge, Carlos Caldas lab).
With this analysis, we aim to assess the relevance of CDH1 locus loss in breast cancer prognosis and progression.
Description: Breast cancer is the most incident and the fifth most mortal cancer worldwide, being the deadliest cancer in females [1]. Current knowledge has highlighted the expression of hormone receptors (estrogen and progesterone) and HER2 as important drivers of clinical intervention and patient care [2].
Additionally, different molecular signatures have been identified in breast cancer with potential prognostic and therapeutic value [3-6], but none has been brought into clinical practice so far.
The 16q loss is one of the most studied chromosomal abnormalities and the second most frequent in breast cancer [7-11], just after 1q gain [12,13]. However, its biological impact and relationship with clinical features have not yet been characterized.
CDH1, encoding the E-cadherin protein, is a well-known tumor suppressor gene located at the 16q chromosome arm, with a proven role in gastric and breast carcinogenesis [14, 15]. While CDH1 complete loss of function (homozygous inactivation) is considered the trigger for the initiation of lobular breast carcinoma [16] and diffuse type gastric cancer [14, 17] partial (heterozygous) or temporary loss of E-cadherin expression is thought to occur during progression of other histological types of gastric and breast cancer [14,18-22].
CDH1 loss of heterozygosity (LOH) has been associated with poor prognosis in intestinal gastric cancer and with lymph node metastasis in sporadic and hereditary diffuse gastric cancer [14, 23]. In breast cancer, loss of 16q chromosome arm occurs in around 30% of the cases [11], and there is an association with good prognosis, since this group is normally characterized by a Luminal A PAM50 subtype [3, 24]. Our purpose is to fine-map deletions in the 16q chromosome arm in a large series of breast cancers from the METABRIC project, and associate the level of CDH1 loss (homozygous or heterozygous) to patients' clinic-pathological features and prognosis (to be performed in Cambridge, Carlos Caldas lab).
With this analysis, we aim to assess the relevance of CDH1 locus loss in breast cancer prognosis and progression.2023-12-07T00:00:00ZTarget-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer Activity by Applying the Heavy-Atom Effect
https://hdl.handle.net/10216/146883
Title: Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer Activity by Applying the Heavy-Atom Effect
Abstract: Photodynamic therapy (PDT) is an anticancer therapeutic modality with remarkable advantages over more conventional approaches. However, PDT is greatly limited by its dependence on external light sources. Given this, PDT would benefit from new systems capable of a light-free and intracellular photodynamic effect. Herein, we evaluated the heavy-atom effect as a strategy to provide anticancer activity to derivatives of coelenterazine, a chemiluminescent single-molecule widespread in marine organisms. Our results indicate that the use of the heavy-atom effect allows these molecules to generate readily available triplet states in a chemiluminescent reaction triggered by a cancer marker. Cytotoxicity assays in different cancer cell lines showed a heavy-atom-dependent anticancer activity, which increased in the substituent order of hydroxyl < chlorine < bromine. Furthermore, it was found that the magnitude of this anticancer activity is also dependent on the tumor type, being more relevant toward breast and prostate cancer. The compounds also showed moderate activity toward neuroblastoma, while showing limited activity toward colon cancer. In conclusion, the present results indicate that the application of the heavy-atom effect to marine coelenterazine could be a promising approach for the future development of new and optimized self-activating and tumor-selective sensitizers for light-free PDT.2021-01-01T00:00:00ZUrinary dysfunction after spinal cord injury: resolving neuronal mechanisms behind neurogenic detrusor overactivity
https://hdl.handle.net/10216/157615
Title: Urinary dysfunction after spinal cord injury: resolving neuronal mechanisms behind neurogenic detrusor overactivity2024-03-06T00:00:00ZPlasticidade da medula espinhal após lesão cerebral unilateral: implicações nos défices motores e envolvimento neurohumoral
https://hdl.handle.net/10216/157626
Title: Plasticidade da medula espinhal após lesão cerebral unilateral: implicações nos défices motores e envolvimento neurohumoral2024-03-07T00:00:00ZIn vitro and in vivo study of an osseointegrable local antibiotic release system for the treatment of osteomyelitis
https://hdl.handle.net/10216/157619
Title: In vitro and in vivo study of an osseointegrable local antibiotic release system for the treatment of osteomyelitis2024-03-08T00:00:00ZOccurrence of Psychiatric Comorbidities in Hyperacusis and Misophonia - a Systematic Review
https://hdl.handle.net/10216/157192
Title: Occurrence of Psychiatric Comorbidities in Hyperacusis and Misophonia - a Systematic Review
Abstract: Introduction: Decreased sound tolerance among individuals can be divided into two conditions: Hyperacusis and Misophonia. Hyperacusis is the perception of certain everyday sounds as excessively loud or painful. Misophonia, on its hand, is characterized by heightened emotional reaction to a sound with a specific pattern and/or meaning to an individual, with the context in which it occurs being relevant. Scattered evidence from clinical research suggests that Hyperacusis and Misophonia can co-occur with a wide range of psychiatric disorders. The coexistence of a psychiatric comorbidity can affect the severity of the symptoms and, subsequently, the clinical management of these patients. A better understanding of these comorbid conditions is important as it could help to clarify their underlying mechanisms and ultimately to improve the care provided to individuals experiencing them.
Objective: To conduct a systematic review of the available evidence on the prevalence of psychiatric disorders in patients with Hyperacusis and Misophonia, and to explore which factors may influence prevalence estimates.
Methods: This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting statement. A protocol was registered in the PROSPERO database (registration number CRD42022347013). The review question was formulated using the CoCoPop (Condition, Context and Population) framework for prevalence and/or incidence reviews and informed the selection criteria. Systematic searches were conducted in four bibliographic electronic databases - PubMed, PsycINFO, Scopus and Web of Science - from inception to 7th of January 2023 to identify relevant studies. The searches were limited to human studies and no date, language or country origin restrictions were applied. The search strategy encompassed terms for "Hyperacusis and Misophonia" and terms related to "Psychiatric Comorbidities". Two authors (ALR and DR) independently screened titles/abstracts and full text articles following the predefined inclusion criteria. The methodological quality and risk of bias were assessed using Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Prevalence and Case-Control studies. Because the studies included were of diverse populations and include a wide range of psychopathology, the data were tabulated and a narrative analysis was conducted.
Results: Out of 663 records initially retrieved, a total of 14 studies, involving 2313 patients, were found to meet the inclusion criteria for this review. Among them, 10 studies focused on describing the prevalence of psychiatric comorbidities in individuals with Misophonia and 4 studies examined psychiatric comorbidities in individuals with Hyperacusis.
Conclusion: This is the first systematic review to report prevalence data of psychiatric comorbidities in Misofonia and Hyperacusis. Despite the heterogeneity observed among the included studies, the available evidence consistently points to a significant prevalence of a wide range of psychiatric comorbidities in patients with Hyperacusis and Misophonia. This finding underscores the importance of screening individuals affected by these conditions for psychiatric disorders.
Description: Introdução: A sensibilidade sonora patológica pode ser dividida em duas condições: a Hiperacusia e a Misofonia. A Hiperacusia é a perceção de certos sons do dia-a-dia como excessivamente altos ou até mesmo dolorosos. A Misofonia é caracterizada por uma reação emocional intensificada a um som com um padrão e/ou significado individual, num contexto específico de ocorrência. Estudos recentes mostram que a Hiperacusia e a Misofonia podem ser comórbidas e associadas a morbilidade psiquiátrica. Isto pode ter um impacto na severidade dos sintomas e, consequentemente, na abordagem clínica dos pacientes. Uma melhor compreensão da relação entre estas duas condições e comorbilidades psiquiátricas é importante, para a compreensão dos mecanismos de doença subjacentes, melhorando assim a orientação destes pacientes.
Objetivo: Neste estudo, o nosso propósito foi realizar uma revisão sistemática, de forma a avaliar a ocorrência de comorbilidades psiquiátricas em pacientes com Hiperacusia e em pacientes com Misofonia e explorar quais os fatores que podem influenciar a sua prevalência.
Metodologia: Foi realizada uma revisão sistemática de acordo com as orientações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Esta revisão sistemática foi registada na base de dados PROSPERO com o número de registo CRD42022347013. A questão de investigação foi formulada usando o modelo CoCoPop (Condition, Context and Population) para estudos de evidência de prevalência e incidência. Foi efetuada uma pesquisa de literatura nas seguintes 4 bases de dados: PubMed, PsycINFO, Scopus e Web of Science, até 7 de Janeiro de 2023, com a finalidade de identificar estudos relevantes. Esta pesquisa foi limitada a estudos humanos, sem nenhuma restrição de data, idioma ou país de origem aplicada. A estratégia de pesquisa incluiu termos para "Hiperacusia e Misofonia" e termos relacionados a "Comorbilidades Psiquiátricas". Dois investigadores (ALR e DR), atuando de forma independente, selecionaram os artigos de acordo com os critérios de elegibilidade. O risco de viés dos estudos foi avaliado através das ferramentas do Joanna Briggs Institute (JBI) para estudos de prevalência e caso-controle. Uma vez que os estudos apresentam uma grande heterogeneidade relativamente à população estudada e comorbilidades psiquiátricas relatadas, uma análise narrativa foi realizada.
Resultados: Após o processo de seleção entre 663 artigos, 14 artigos cumpriram os critérios de inclusão, com um total de 2313 pacientes. Dos 14 artigos incluídos, 10 relatam comorbilidades psiquiátricas em indivíduos com Misofonia e 4 relatam comorbilidades psiquiátricas em indivíduos com Hiperacusia.
Conclusão: Esta é a primeira revisão sistemática que reúne informação existente acerca de dados de prevalência de comorbilidades psiquiátricas em Misofonia e Hiperacusia. Apesar da heterogeneidade observada entre os estudos, a evidência aponta para uma prevalência significativa de comorbilidades psiquiátricas, em pacientes com Misofonia e Hiperacusia. Os resultados encontrados corroboram a importância do rastreio destes pacientes para perturbações psiquiátricas. 2023-12-06T00:00:00ZControlar a Dor em doentes com demência avançada: o papel dos biomarcadores na caracterização da dor e a importância da farmacocinética na estratégia terapêutica para doentes em Cuidados Paliativos.
https://hdl.handle.net/10216/157598
Title: Controlar a Dor em doentes com demência avançada: o papel dos biomarcadores na caracterização da dor e a importância da farmacocinética na estratégia terapêutica para doentes em Cuidados Paliativos.2024-03-05T00:00:00ZA modificação do arco de contacto na Cirurgia do estrabismo
https://hdl.handle.net/10216/157506
Title: A modificação do arco de contacto na Cirurgia do estrabismo2024-02-26T00:00:00ZDesenvolvimento de um programa de ensino e avaliação da Psiquiatria e Saúde Mental no curso de medicina em Moçambique.
https://hdl.handle.net/10216/157504
Title: Desenvolvimento de um programa de ensino e avaliação da Psiquiatria e Saúde Mental no curso de medicina em Moçambique.2024-02-26T00:00:00ZLesbian Shared Ivf - The ROPA Method
https://hdl.handle.net/10216/157058
Title: Lesbian Shared Ivf - The ROPA Method2024-01-31T00:00:00ZCaspase-3 and bcl-2 expression in aging in adrenal zona reticularis after dexamethasone administration
https://hdl.handle.net/10216/99477
Title: Caspase-3 and bcl-2 expression in aging in adrenal zona reticularis after dexamethasone administration
Abstract: Adrenocortical cell death by apoptosis is a common finding when adrenocorticotropic hormone is suppressed. Despite the well-known final structural features exhibited by those cells, data on the mechanisms preceding these final events are lacking. In this study, after 3 days of dexamethasone administration to rats of different ages, rat adrenals were processed for immunocytochemical study. In the zona reticularis, there was evidence of the activation of Bcl-2 and caspase-3 proteins. Beyond a small age-related increase in labeled cells, the number of cells presenting colocalization for both proteins was noteworthy. The results confirm the involvement of Bcl-2 and caspase-3 proteins in the apoptotic pathway and suggest their simultaneous intervention.2007-01-01T00:00:00ZThe effects of a video-based randomized controlled trial intervention on depression stigma and help-seeking attitudes in university students
https://hdl.handle.net/10216/157281
Title: The effects of a video-based randomized controlled trial intervention on depression stigma and help-seeking attitudes in university students
Abstract: University students are a risk group for developing mental illness, but they do not receive the care they need because of hampered help-seeking induced by stigma. This study evaluates the effects of a video-based stigma reduction intervention and help-seeking attitudes promotion in university students. We randomly distributed a sample of university students among one control group (CG, n = 188) and two intervention groups (IG-1, n = 222 and IG-2, n = 216): IG-1 watched a contact-based video and IG-2 the same video plus a psychoeducational video. The study followed an experimental single-blind randomized control trial design with a pre-test before the intervention (M0), a post-test, and a follow-up test. We evaluated participants using a sociodemographic questionnaire, the Attitudes Toward Seeking Professional Psychological Help Questionnaire, the Depression Stigma Scale, the 9-item Patient Health Questionnaire, and the 7-item Generalized Anxiety Disorder. A total of 626 participants with a mean age of 19.85 (SD=1.48) responded to all evaluation moments. At M0, there were no differences between groups on stigma or help-seeking attitudes. Immediately after the intervention, stigma levels significantly decreased, and help-seeking attitudes significantly improved. These effects persisted for the next five months. Video-based depression stigma reduction intervention can be an essential tool to reduce depression stigma and improve help-seeking attitudes. (c) 2021 Elsevier B.V.2022-01-01T00:00:00ZStereotypies in Autism Spectrum Disorder
https://hdl.handle.net/10216/145797
Title: Stereotypies in Autism Spectrum Disorder2022-11-25T00:00:00Z