Individual and institutional factors associated with the quality of life of portuguese older adults living in nursing homes

Methods: This cross-sectional study involved 22 nursing homes from the central region of Portugal and a total of 213 institutionalized older adults aged 60 or older without cognitive impairment, selected through random cluster sampling. Participants were interviewed using a structured questionnaire to collect data on sociodemographic, lifestyle behaviours, and information related to their nursing home experience. Institutional characteristics were reported by the Technical Director of each nu...

The value of doctoral education in the intersection of the multiple purposes of higher education

Cardiotoxicidade associada à terapêutica oncológica: mecanismos fisiopatológicos e estratégias de prevenção

Cardiotoxicity is one of the most significant adverse effects of cancer treatment, and is responsible for considerable morbidity and mortality. Among the effects of chemotherapeutic agents on the cardiovascular system, the most frequent and serious is heart failure with ventricular systolic dysfunction. Other toxic effects include hypertension, thromboembolic disease, pericardial disease, arrhythmias and myocardial ischemia. For several decades, cancer therapy-induced cardiomyopathy was almos...

Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer Activity by Applying the Heavy-Atom Effect

Photodynamic therapy (PDT) is an anticancer therapeutic modality with remarkable advantages over more conventional approaches. However, PDT is greatly limited by its dependence on external light sources. Given this, PDT would benefit from new systems capable of a light-free and intracellular photodynamic effect. Herein, we evaluated the heavy-atom effect as a strategy to provide anticancer activity to derivatives of coelenterazine, a chemiluminescent single-molecule widespread in marine organ...