https://hdl.handle.net/10216/73101 2026-07-18T18:12:03Z 2026-07-18T18:12:03Z https://hdl.handle.net/10216/169500 2026-04-22T06:27:14Z 2025-05-27T00:00:00Z

Title: Photodynamic inactivation of methicillin-resistant Staphylococcus aureus using harmine-antiseptic combinations

2025-05-27T00:00:00Z https://hdl.handle.net/10216/144275 2026-03-17T07:45:48Z 2022-01-01T00:00:00Z

Title: Patterns of street food purchase in cities from Central Asia (vol 9, 925771, 2022) [correction] Abstract: In the published article, there was an error in Figure 5 as published. The legend for the red bars was Industrial only and the legend for the green bars was Homemade and industrial.However, these legends weremistakenly switched. As such, the correct legend for the red bars is Homemade and industrial and the correct legend for the green bars is Industrial only. The corrected Figure 5 and its caption appear below. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. (c) 2022 Sousa, Lança de Morais,Albuquerque, Gelormini, Casal, Pinho, Motta, Damasceno, Moreira, Breda, Lunet and Padrão.

2022-01-01T00:00:00Z https://hdl.handle.net/10216/72861 2026-01-20T07:37:29Z 2013-01-01T00:00:00Z

Title: Cardiotoxicity associated with cancer therapy: Pathophysiology and prevention strategies Abstract: Cardiotoxicity is one of the most significant adverse effects of cancer treatment, and is responsible for considerable morbidity and mortality. Among the effects of chemotherapeutic agents on the cardiovascular system, the most frequent and serious is heart failure with ventricular systolic dysfunction. Other toxic effects include hypertension, thromboembolic disease, pericardial disease, arrhythmias and myocardial ischemia. For several decades, cancer therapy-induced cardiomyopathy was almost exclusively associated with the use of cumulative doses of anthracyclines, which cause permanent damage at the cellular level. However, new therapeutic agents, such as the monoclonal antibody trastuzumab, induce transient reversible myocyte dysfunction which is unrelated to the dose used. Early identification of potential cardiovascular injury, accurate diagnosis of cardiotoxic events and implementation of appropriate monitoring plans are essential in patients with cancer. Close cooperation between cardiologists and oncologists is thus crucial, in order to balance the risks and benefits of cardiotoxic anticancer therapy. In this article we review the various responses to cardiotoxic cancer treatments and their relationship with the main antineoplastic drugs used in clinical practice. In addition, we discuss the main guidelines on detection and monitoring of cardiotoxicity in patients with cancer.

2013-01-01T00:00:00Z https://hdl.handle.net/10216/151316 2025-12-19T07:18:47Z 2023-01-01T00:00:00Z

Title: Author Correction: Global dietary quality in 185 countries from 1990 to 2018 show wide differences by nation, age, education, and urbanicity(19 september, 10.1038/s43016-022-00594-9, 2022) Abstract: [No abstract available]

2023-01-01T00:00:00Z https://hdl.handle.net/10216/157132 2025-03-11T07:21:43Z 2023-01-01T00:00:00Z

Title: A Giant Gastric Lipoma

2023-01-01T00:00:00Z https://hdl.handle.net/10216/110402 2025-03-08T07:21:50Z 2018-01-01T00:00:00Z

Title: Powdered chicken stock may be an important source of dietary sodium intake in Maputo, Mozambique

2018-01-01T00:00:00Z https://hdl.handle.net/10216/157138 2025-03-06T07:23:08Z 2023-01-01T00:00:00Z

Title: Synchronous Tumors: Minimally Invasive Surgery for Esophageal and Lung Cancer Abstract: Introduction: Synchronous esophageal and lung cancer is an uncommon entity with few descriptions in the literature. It poses a relevant challenge to health care providers regarding its management and surgical approach. Case report: We present the case of a 73-year-old male diagnosed with lung squamous-cell carcinoma after admission for a history of productive cough and episodic hemoptysis. An esophageal squamous-cell carcinoma was diagnosed. Both tumors were histologically different. A surgical procedure was conducted with concomitant esophagectomy and lobectomy. The patient had no postoperative complications and was discharged home after 15 days post-surgery. Conclusions: The diagnosis of synchronous tumors is challenging and should be based on clinical, imaging and histological criteria. Choosing to perform a surgical procedure for resection of both tumors in the same operative time represents a technical challenge, but has shown to have good impact on morbidity and mortality. Documenting such cases is important in order to improve management of these clinical situations, allowing for better outcomes for these patients. (c) Celsius Publishing House.

2023-01-01T00:00:00Z https://hdl.handle.net/10216/156873 2025-02-22T07:22:12Z 2023-01-01T00:00:00Z

Title: Reducing Dietary Sodium and Improving Human Health 2.0 Abstract: [No abstract available]

2023-01-01T00:00:00Z https://hdl.handle.net/10216/131303 2024-10-11T06:19:56Z 2020-01-01T00:00:00Z

Title: Dose-response relationships in health risk assessment of nutritional and toxicological factors in foods: development and application of novel biostatistical methods

2020-01-01T00:00:00Z https://hdl.handle.net/10216/144241 2024-09-20T06:19:25Z 2022-01-01T00:00:00Z

Title: Food, nutrition and diet in urban areas from low and middle-income countries in the World Health Organization European Region

2022-01-01T00:00:00Z https://hdl.handle.net/10216/146769 2024-08-15T06:18:25Z 2022-01-01T00:00:00Z

Title: Corrigendum to "Uptake and translocation of UV-filters and synthetic musk compounds into edible parts of tomato grown in amended soils Abstract: The authors regret that the printed version of the above article contained a number of errors. The correct and final version follows. The authors would like to apologise for any inconvenience caused. Unfortunately, an author was inadvertently omitted from the list of authors and affiliations in the original publication. The complete list should read as follows: Sara Ramos1, Pedro Humberto Castro2,3, Vera Homem1,, Lúcia Santos1 1LEPABE Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal 2CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade do Porto, 4485-661 Vairão, Portugal 3BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vairão, 4485-661 Vairão, Portugal Corresponding author. (c) 2021 Elsevier B.V.

2022-01-01T00:00:00Z https://hdl.handle.net/10216/130562 2023-06-10T06:22:41Z 2020-01-01T00:00:00Z

Title: Billboard food advertising in Maputo, Mozambique: a sign of nutrition transition

2020-01-01T00:00:00Z https://hdl.handle.net/10216/143836 2022-12-06T07:25:38Z 2021-01-01T00:00:00Z

Title: Gold-Mushroom Microelectrode Arrays and the Quest for Intracellular-Like Recordings: Perspectives and Outlooks Abstract: The ongoing search to decode the brain communication system has propelled major advancements in bioelectronics research. From these, planar microelectrode arrays (MEAs) offer the possibility to record neuronal signals for extremely long periods of time and to probe fundamental principles of learning and adaptation. Unfortunately, MEAs have low neuronal coupling and are thus insensitive to sub-threshold neuronal signals such as post-synaptic responses. To surpass this major limitation, a novel category based on 3D high aspect ratio microstructures has emerged. In particular, gold-mushroom microelectrode arrays (GM mu EAs) have appeared as a solution. Their unique morphology, promoting cell engulfment without penetrating the neuron, prevents the occurrence of cell repairing mechanisms common in other microelectrodes. This new class of recording and/or stimulating devices have opened the door to the vast communication system of neuronal cells by enhancing the cell-microelectrode interface. This review compiles the fundamentals of these promising devices including their fabrication, work principles and focusing on how the different morphological parameters affect the recording performance. Although limitations exist, there is a growing interest to explore the new solutions that GM mu EAs still offer, both as an electrophysiological tool (e.g., cell guidance) or in applications such as plasmonics.

2021-01-01T00:00:00Z https://hdl.handle.net/10216/111197 2022-10-17T15:20:10Z 2015-01-01T00:00:00Z

Title: Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy Abstract: P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDRI gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer therapy. For several decades, P-gp inhibition has drawn many significant research efforts in an attempt to overcome this phenomenon. However, P-gp is also constitutively expressed in normal human epithelial tissues and, due to its broad substrate specificity, to its cellular polarized expression in many excretory and barrier tissues, and to its great efflux capacity, it can play a crucial role in limiting the absorption and distribution of harmful xenobiotics, by decreasing their intracellular accumulation. Such a defense mechanism can be of particular relevance at the intestinal level, by significantly reducing the intestinal absorption of the xenobiotic and, consequently, avoiding its access to the target organs. In this review, the current knowledge on this important efflux pump is summarized, and a new focus is brought on the therapeutic interest of inducing and/or activating P-gp for limiting the toxicity caused by its substrates. Several in vivo and in vitro studies validating the use of such a therapeutic strategy are discussed. An extensive literature search for reported P-gp inducers/activators and for the experimental models used in their characterization was conducted. Those studies demonstrate that effective antidotal pathways can be achieved by efficiently promoting the P-gp-mediated efflux of deleterious xenobiotics, resulting in a significant reduction in their intracellular levels and, consequently, in a significant reduction of their toxicity.

2015-01-01T00:00:00Z https://hdl.handle.net/10216/90453 2022-10-19T11:01:35Z 2016-01-01T00:00:00Z

Title: Human and experimental toxicology of orellanine Abstract: Orellanine is a nephrotoxic toxin produced by some mushroom species of the Cortinarius genus, typically found in Europe and North America. The nephrotoxicity of Cortinarius orellanus is well known. and was first recognized in the I 950s when this mushroom was identified as the cause of a mass poisoning in Poland. Typically, onset of symptoms is delayed for 1-2 weeks after ingestion. Some patients suffer mild gastrointestinal discomfort in the latency period before developing signs of renal impairment due to severe interstitial nephritis, acute focal tubular damage, and interstitial fibrosis. There is no specific antidote to orellanine poisoning. The mainstay of treatment is the prevention of secondary complications of kidney failure, adequate dialysis and, in the case of incomplete recovery, management of chronic renal insufficiency. In this work, we aim to review about Cortinarius species, including epidemiological studies, chemical structure, toxicokinetics, toxic doses, mechanisms of toxicity, diagnosis, prognosis, and treatment options.

2016-01-01T00:00:00Z https://hdl.handle.net/10216/90435 2022-10-15T13:51:12Z 2015-01-01T00:00:00Z

Title: Biological Evidence Management for DNA Analysis in Cases of Sexual Assault Abstract: Biological evidence with forensic interest may be found in several cases of assault, being particularly relevant if sexually related. Sexual assault cases are characterized by low rates of disclosure, reporting, prosecution, and conviction. Biological evidence is sometimes the only way to prove the occurrence of sexual contact and to identify the perpetrator. The major focus of this review is to propose practical approaches and guidelines to help health, forensic, and law enforcement professionals to deal with biological evidence for DNA analysis. Attention should be devoted to avoiding contamination, degradation, and loss of biological evidence, as well as respecting specific measures to properly handle evidence (i.e., selection, collection, packing, sealing, labeling, storage, preservation, transport, and guarantee of the chain custody). Biological evidence must be carefully managed since the relevance of any finding in Forensic Genetics is determined, in the first instance, by the integrity and quantity of the samples submitted for analysis. (c) 2015 Teresa Magalhães et al.

2015-01-01T00:00:00Z https://hdl.handle.net/10216/90462 2022-10-19T09:44:41Z 2016-01-01T00:00:00Z

Title: Response to the comment on "Promising blood-derived biomarkers for estimation of the postmortem interval" Abstract: Following Meurs and Szykula's comment on our published article titled "Promising blood-derived biomarkers for estimation of the postmortem interval", we recognize the importance of the issues raised, but we would like to emphasize that these contain some misinterpretations and that most of the points were already discussed in depth in our manuscript particularly in the conclusion section. We also aim to highlight further data regarding the difficulties of postmortem interval estimation.

2016-01-01T00:00:00Z https://hdl.handle.net/10216/90506 2022-10-17T17:29:44Z 2016-01-01T00:00:00Z

Title: Metabolomics of methadone: clinical and forensic toxicological implications and variability of dose response Abstract: Methadone is a full -opioid receptor agonist used in the treatment of heroin addiction. It is commercialized as a racemic mixture with considerable variability in the pharmacokinetics and pharmacodynamics between individuals that can affect dose-response and toxicological profile. This review aims to discuss metabolomics of methadone, namely by presenting all major and minor metabolites and pharmacokinetic drug interactions. The main mechanism for methadone metabolism is hepatic through the cytochrome P450, specifically isoenzymes 2B6, 3A4 and 2D6. Firstly, methadone is N-demethylated and cyclize to form its major 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyraline (EMDP) metabolites. Several alternate minor pathways have been described namely various methadol metabolites, which proved to be active.It is expected that knowing the metabolomics of methadone may provide further insights, attempting a personalized therapy aiming to attain effective blood concentrations. The historical record is therefore especially important when investigating clinical and forensic cases related to methadone administration, since interindividual responses are known to vary considerably.

2016-01-01T00:00:00Z https://hdl.handle.net/10216/141314 2022-10-16T12:54:50Z 2018-01-01T00:00:00Z

Title: Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics Abstract: With the dramatic consequences of bacterial resistance to antibiotics, nanomaterials and molecular transporters have started to be investigated as alternative antibacterials or anti-infective carrier systems to improve the internalization of bactericidal drugs. However, the capability of nanomaterials/molecular transporters to overcome the bacterial cell envelope is poorly understood. It is critical to consider the sophisticated architecture of bacterial envelopes and reflect how nanomaterials/molecular transporters can interact with these envelopes, being the major aim of this review. The first part of this manuscript overviews the permeability of bacterial envelopes and how it limits the internalization of common antibiotic and novel oligonucleotide drugs. Subsequently we critically discuss the mechanisms that allow nanomaterials/molecular transporters to overcome the bacterial envelopes, focusing on the most promising ones to this end - siderophores, cyclodextrins, metal nanoparticles, antimicrobial/cell-penetrating peptides and fusogenic liposomes. This review may stimulate drug delivery and microbiology scientists in designing effective nanomaterials/molecular transporters against bacterial infections.

2018-01-01T00:00:00Z https://hdl.handle.net/10216/90473 2022-10-15T11:52:24Z 2015-01-01T00:00:00Z

Title: Metabolomics of cocaine: implications in toxicity Abstract: Cocaine is the most commonly used illicit drug among those seeking care in Emergency Departments or drug detoxification centers. Cocaine, chemically known as benzoylmethylecgonine, is a naturally occurring substance found in the leaves of the Erythroxylum coca plant. The pharmacokinetics of cocaine is dependent on multiple factors, such as physical/chemical form, route of administration, genetics and concurrent consumption of alcohol. This review aims to discuss metabolomics of cocaine, namely by presenting all known metabolites of cocaine and their roles in the cocaine-mediated toxic effects.

2015-01-01T00:00:00Z