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https://hdl.handle.net/10216/98164
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DC Field | Value | Language |
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dc.creator | Faria, Ana | |
dc.creator | Pestana, D | |
dc.creator | Teixeira, D | |
dc.creator | Azevedo, J | |
dc.creator | Victor de Freitas | |
dc.creator | Nuno Mateus | |
dc.creator | Conceicao Calhau | |
dc.date.accessioned | 2022-09-06T21:44:27Z | - |
dc.date.available | 2022-09-06T21:44:27Z | - |
dc.date.issued | 2010 | |
dc.identifier.issn | 1425-8153 | |
dc.identifier.other | sigarra:48318 | |
dc.identifier.uri | https://hdl.handle.net/10216/98164 | - |
dc.description.abstract | There is a growing interest in dietary therapeutic strategies to combat oxidative stress-induced damage to the Central Nervous System (CNS), which is associated with a number of pathophysiological processes, including Alzheimer's and Parkinson's diseases and cerebrovascular diseases. Identifying the mechanisms associated with phenolic neuroprotection has been delayed by the lack of information concerning the ability of these compounds to enter the CNS. The aim of this study was to evaluate the transmembrane transport of flavonoids across RBE-4 cells (an immortalized cell line of rat cerebral capillary endothelial cells) and the effect of ethanol on this transport. The detection and quantification of all of the phenolic compounds in the studied samples (basolateral media) was performed using a HPLC-DAD (Diode Array Detector). All of the tested flavonoids (catechin, quercetin and cyanidin-3-glucoside) passed across the RBE-4 cells in a time-dependent manner. This transport was not influenced by the presence of 0.1% ethanol. In conclusion, the tested flavonoids were capable of crossing this blood-brain barrier model. | |
dc.language.iso | eng | |
dc.rights | restrictedAccess | |
dc.subject | Biologia molecular, Espectroquímica, Citoquímica, Engenharia química | |
dc.subject | Molecular biology, Spectrochemistry, Cytochemistry, Chemical engineering | |
dc.title | Flavonoid transport across RBE4 cells: A blood-brain barrier model | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Faculdade de Ciências da Nutrição e Alimentação | |
dc.contributor.uporto | Faculdade de Ciências | |
dc.contributor.uporto | Faculdade de Medicina | |
dc.identifier.doi | 10.2478/s11658-010-0006-4 | |
dc.identifier.authenticus | P-003-5WT | |
dc.subject.fos | Ciências da engenharia e tecnologias::Engenharia química | |
dc.subject.fos | Engineering and technology::Chemical engineering | |
Appears in Collections: | FCNAUP - Artigo em Revista Científica Internacional FCUP - Artigo em Revista Científica Internacional FMUP - Artigo em Revista Científica Internacional |
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File | Description | Size | Format | |
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48318.pdf Restricted Access | 909.42 kB | Adobe PDF | Request a copy from the Author(s) |
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