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Author(s): Meireles, M.
Moura, E.
Vieira-Coelho, M.A.
Santos-Buelga, C.
Gonzalez-Manzano, S.
Dueñas, M.
Mateus, N.
Faria, Ana
Calhau, C.
Title: Flavonoids as dopaminergic neuromodulators
Issue Date: 2016
Abstract: SCOPE: The present study aimed to characterize and evaluate flavonoids effects on organic cation uptake in neuronal cells. METHODS AND RESULTS: Uptake experiments were conducted using radiolabeled methyl-4-phenylpyridinuim ([3 H]-MPP+ ), in human neuronal dopaminergic cells, SH-SY5Y. Catechin did not alter [3 H]-MPP+ uptake, however its metabolite 4'-methyl-catechin decreased it by almost 50%. Epicatechin and its methylated metabolites also decreased [3 H]-MPP+ uptake. Interestingly, the quercetin flavonol and its metabolite conjugated with glucuronic acid, as well as the flavanones naringenin and hesperitin, increased [3 H]-MPP+ uptake. CONCLUSION: These results showed that different classes of flavonoids, as well as its metabolites, differently influence neuronal organic cation uptake. Several xeno- and endobiotics, including neurotransmitters, are organic cations. Specific food recommendations may be beneficial in pathological conditions where levels of neurotransmitters, as dopamine, are either increased or decreased. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved. KEYWORDS: Dopamine transporter; Dopaminergic cells; Flavonoids; Methyl-4-phenylpyridinuim; Organic cation transport
Subject: Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCNAUP - Artigo em Revista Científica Internacional
FCUP - Artigo em Revista Científica Internacional
FMUP - Artigo em Revista Científica Internacional

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