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Author(s): Marques, Claúdia
Iva Fernandes
Norberto, Sónia
Sá-Couto CD
Teixeira, Diana
Freitas, Victor de
Nuno Mateus
Conceicao Calhau
Faria, Ana
Title: Pharmacokinetics of blackberry anthocyanins consumed with or without ethanol: A randomized and crossover trial
Issue Date: 2016
Abstract: Scope: This study was designed to evaluate the influence of ethanol on the bioavailability of blackberry anthocyanins.Methods and results: A total of 18 participants were recruited to consume 250 mL of a blackberry puree (650 mg of anthocyanins) without (BBP) or with 12% ethanol (BBP 12%). Venous blood was collected from participants at baseline and at 15, 30, 60, and 120 min after puree ingestion. Urine samples were collected at baseline and at 120 min. Plasma and urine concentration of anthocyanins and anthocyanin conjugates were quantified by HPLC-DAD. Methylcyanidin- glucuronide (Me-Cy-Glucr) and 3-methyl-cyanidin-3-glucoside (3-Me-Cy3glc) were the main anthocyanin conjugates detected in all plasma and urine samples. Urinary concentration of these anthocyanin conjugates were positively correlatedwith their plasma concentration. Ethanol increased plasma Cmax of Me-Cy-Glucr and 3-Me-Cy3glc. Participants were then stratified according to their body mass index (BMI) and body fat mass. After BBP consumption, plasma Cmax of Me-Cy-Glucr and 3-Me-Cy3glc tended to be decreased in overweight/obese participants, in comparison to normal weight participants. The increase on plasma Cmax of Me-Cy-Glucr and 3-Me-Cy3glc induced by ethanol was more pronounced in the group of overweight/obese participants.Conclusions: Ethanol seems to enhance Cy3glc metabolism that appears to be compromised in overweight and obese individuals.
Subject: Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCNAUP - Artigo em Revista Científica Internacional
FCUP - Artigo em Revista Científica Internacional
FMUP - Artigo em Revista Científica Internacional

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