Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/86776
Author(s): | Norberto, Sónia Conceicao Calhau Pestana, Diogo Faria, Ana |
Title: | Effects of environmental pollutants on MCF-7 Cells: A metabolic approach |
Issue Date: | 2017 |
Abstract: | Several environmental pollutants (EPs) have been associated with biological and molecular processes leading to adverse human health effects, including different types of cancer. Nevertheless, the effects exerted on tumor glucose metabolism are unclear. To evaluate the effects on cellular and molecular mechanisms, namely glucose metabolism, MCF-7 cells were exposed to EPs during short- and long-term exposures. The effect of both, organochlorine pesticides and plasticizing agents, on glucose uptake by MCF-7 cells was not dose-dependent and was affected by time of exposure. The HCH and BPA increased glucose uptake after 20min. Long-term exposure to 250nM of organochlorine pesticides (p,p'-DDE and HCH) and BPA increased cell proliferation. However, only the organochlorine pesticides were able to increase lactate production, without a concomitant higher glucose uptake or glycolytic enzymes transcription. Given their distinct persistent profiles, the biological significance of their exposure should be considered accordingly |
Subject: | Ciências da Saúde, Ciências médicas e da saúde Health sciences, Medical and Health sciences |
Scientific areas: | Ciências médicas e da saúde Medical and Health sciences |
URI: | https://repositorio-aberto.up.pt/handle/10216/86776 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | FCNAUP - Artigo em Revista Científica Internacional FMUP - Artigo em Revista Científica Internacional |
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166675.pdf Restricted Access | 958.13 kB | Adobe PDF | Request a copy from the Author(s) |
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