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Author(s): Hernani Goncalves
Tiago Henriques Coelho
Ana Paula Rocha
Andre P Lourenco
Adelino Leite Moreira
Joao Bernardes
Title: Comparison of different methods of heart rate entropy analysis during acute anoxia superimposed on a chronic rat model of pulmonary hypertension
Issue Date: 2013
Abstract: Acute life-threatening situations are particularly critical when superimposed on chronic diseases. The objective of this study was the assessment of heart rate (HR) dynamics during episodes of acute anoxia superimposed on a rat model of chronic pulmonary hypertension. In 10 adult Wistar rats, five weeks after pulmonary hypertension induction with Monocrotaline, we analysed eight 1-min HR segments, during episodes of baseline, mechanical ventilation and acute anoxia, using linear indices, approximate entropy (ApEn), sample entropy (SampEn) and multiscale entropy (MSE). The transition from baseline or mechanical ventilation to early anoxia was identified through almost all indices, but SampEn(2,0.6) was the index that better identified all the transitions. MSE presented limited performance, possibly due to the non-stationary nature and short duration of the acute anoxia episodes. A systematic evaluation of all computed HR indices may help to identify which indices or combination of indices more adequately discriminates and monitors critical acute events superimposed on chronic clinical conditions.
Subject: Biotecnologia ambiental
Environmental biotechnology
Scientific areas: Ciências da engenharia e tecnologias::Biotecnologia ambiental
Engineering and technology::Environmental biotechnology
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FCUP - Artigo em Revista Científica Internacional
FMUP - Artigo em Revista Científica Internacional

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