LC-MS identification of derivatized free fatty acids from adipocere in soil samples
Free fatty acids were derivatized as amides (DFFA) by reaction with (R)-(+)-1-phenyl-ethylamine, using a simple, fast and robust reaction scheme. A HPLC method with diode array and ESI MS detection was developed for the analysis of the derivatized substances. Six fatty acids were used in the method development: myristic, linoleic, palmitic, oleic, margaric and stearic acids. Under these conditions the elution of the DFFA are well resolved with retention times raging from 6.9 to 16.0 min. Fatt...
Synthesis of methyl (+/-)-3,5-bis(substitutedmethyl)pyrrolidine-2-carboxylates: a convenient approach to proline-mimetics
Starting from readily available N-benzyl protected methyl 3,5-bis(hydroxymethyl)pirrolidinecarboxylate a number of racemic methyl t-3,t-5-disubstitutedprolinates have been synthesised, thus opening a practical way towards the preparation of a variety of putative proline-mimetics. In this context, N-Boc protected derivatives proved to be better intermediates than their N-benzyl counterparts in terms of cleanness and overall yield of the synthetic procedure.
Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A(2B) receptor antagonists
A new series of 9-deazaxanthine derivatives with various substituents at the heterocyclic system were synthesized and evaluated for their binding affinities for the four human recombinant adenosine receptors, A(1)-A(3) subtypes. A number of the 9-deazaxanthines derivatives 3a-m showed moderate-to-high affinity for hA(2B) receptors, with compound 3f showing a 32-fold selectivity for A(2B) over A(1) and a 2750-fold selectivity for A(2B) over A(2A).
THE USE OF SIMILARITY IMAGES ON MULTI-SENSOR AUTOMATIC IMAGE REGISTRATION
Automatic image registration (AIR) is still a present challenge regarding remote sensing applications. Although several methods have been proposed in the last few years, geometric correction is often a time and effort consuming manual task. The only AIR method which is commonly used is the correlation-based template matching method. It usually consists on considering a window from one image and passing it throughout the other, looking for a maximum of correlation, which may be associated to t...