Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/99477
Author(s): | Henrique Almeida Liliana Matos Delminda Neves |
Title: | Caspase-3 and bcl-2 expression in aging in adrenal zona reticularis after dexamethasone administration |
Issue Date: | 2007 |
Abstract: | Adrenocortical cell death by apoptosis is a common finding when adrenocorticotropic hormone is suppressed. Despite the well-known final structural features exhibited by those cells, data on the mechanisms preceding these final events are lacking. In this study, after 3 days of dexamethasone administration to rats of different ages, rat adrenals were processed for immunocytochemical study. In the zona reticularis, there was evidence of the activation of Bcl-2 and caspase-3 proteins. Beyond a small age-related increase in labeled cells, the number of cells presenting colocalization for both proteins was noteworthy. The results confirm the involvement of Bcl-2 and caspase-3 proteins in the apoptotic pathway and suggest their simultaneous intervention. |
Subject: | Endocrinologia, Biologia celular, Medicina clínica Endocrinology, Cell biology, Clinical medicine |
Scientific areas: | Ciências médicas e da saúde::Medicina clínica Medical and Health sciences::Clinical medicine |
URI: | https://hdl.handle.net/10216/99477 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | FCNAUP - Artigo em Revista Científica Internacional FMUP - Artigo em Revista Científica Internacional |
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File | Description | Size | Format | |
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47314.pdf Restricted Access | 169.69 kB | Adobe PDF | Request a copy from the Author(s) |
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