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Author(s): Ana Faria
Conceicao Calhau
Title: The Bioactivity of Pomegranate: Impact on Health and Disease
Issue Date: 2011
Abstract: The aim of the present review is to discuss the cumulative evidence that suggests that pomegranate consumption possesses a diverse array of biological actions and may be helpful in the prevention of some inflammatory-mediated diseases including cancer. The pomegranate fruit can be divided into at least three parts-seeds, peel, and juice. All these components have been studied for their antioxidant properties in a chemoprevention approach. Pomegranate exerts antiproliferative, anti-invasive, and antimetastatic effects, induces apoptosis through modulation of Bcl-2 proteins, increases p21 and p27, and downregulates cyclin-cdk network. In addition, pomegranate inhibits the activation of inflammatory pathways including, but not limited to, the NF kappa-B pathway. Anti-cancer effects with the most impressive data have been demonstrated so far in prostate cancer.
Subject: Ciências farmacológicas, Outras ciências agrárias
Pharmacological sciences, Other Agrarian Sciences
Scientific areas: Ciências agrárias::Outras ciências agrárias
Agrarian Sciences::Other Agrarian Sciences
Document Type: Outra Publicação em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCUP - Outra Publicação em Revista Científica Internacional
FMUP - Outra Publicação em Revista Científica Internacional

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