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Author(s): Pedro Almeida
Joana B Vieira
Celeste Silveira
Fernando Ferreira Santos
Pedro L Chaves
Fernando Barbosa
Joao Marques Teixeira
Title: Exploring the dynamics of P300 amplitude in patients with schizophrenia
Issue Date: 2011
Abstract: This study investigated the time-frequency dynamics of P300 generation in patients with first-onset schizophrenia. A group of 40 patients with first-onset schizophrenia and 40 controls performed an auditory oddball task. Wavelet analysis of the single-trial data was used to compute the Event-Related Spectral Perturbation (ERSP) and the Inter-Trial Phase Coherence (ITC) for the delta, theta, alpha, beta and gamma bands on the 50 ms window around peak P300 amplitude. The contribution of power and synchrony for P300 amplitudes was studied through correlation and regression analysis. Further, two sub-samples in which patients had lower or higher P300 amplitudes than their control match were contrasted. P300 amplitude did not differ between patients and controls. The frequency domain analysis revealed that controls display larger reductions on gamma power than patients. However, this gamma activity might be the result of micro-saccadic muscular artifacts. Regression analysis shows that P300 amplitude is highly dependent on delta power and synchronization. The analysis of the subsamples confirmed that while gamma power differences are dependent on the diagnosis, delta and theta synchronization are related to P300 amplitude, irrespective of diagnosis.
Subject: Medicina básica
Basic medicine
Scientific areas: Ciências médicas e da saúde::Medicina básica
Medical and Health sciences::Basic medicine
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/POCI/PSI/58881/2004/Contribuição das alterações do Potencial Evocado P200 para a constituição de um novo endofenótipo da esquizofrenia: um estudo em doentes esquizofrénicos e em familiares em1º grau saudáveis./Potencial Evocado
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FDUP - Artigo em Revista Científica Internacional
FPCEUP - Artigo em Revista Científica Internacional

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