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https://hdl.handle.net/10216/96123
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DC Field | Value | Language |
---|---|---|
dc.creator | Virginia C Fernandes | |
dc.creator | Diogo Pestana | |
dc.creator | Rosario Monteiro | |
dc.creator | Gil Faria | |
dc.creator | Manuela Meireles | |
dc.creator | Luisa Correia Sa | |
dc.creator | Diana Teixeira | |
dc.creator | Ana Faria | |
dc.creator | Conceicao Calhau | |
dc.creator | Valentina F Domingues | |
dc.creator | Cristina Delerue Matos | |
dc.date.accessioned | 2022-09-11T01:50:49Z | - |
dc.date.available | 2022-09-11T01:50:49Z | - |
dc.date.issued | 2012 | |
dc.identifier.issn | 0269-3879 | |
dc.identifier.other | sigarra:46898 | |
dc.identifier.uri | https://hdl.handle.net/10216/96123 | - |
dc.description.abstract | Scientific evidence has shown an association between organochlorine compounds (OCC) exposure and human health hazards. Concerning this, OCC detection in human adipose samples has to be considered a public health priority. This study evaluated the efficacy of various solid-phase extraction (SPE) and cleanup methods for OCC determination in human adipose tissue. Octadecylsilyl endcapped (C18-E), benzenesulfonic acid modified silica cation exchanger (SA), poly(styrene-divinylbenzene (EN) and EN/RP18 SPE sorbents were evaluated. The relative sample cleanup provided by these SPE columns was evaluated using gas chromatography with electron capture detection (GCECD). The C18-E columns with strong homogenization were found to provide the most effective cleanup, removing the greatest amount of interfering substance, and simultaneously ensuring good analyte recoveries higher than 70%. Recoveries?>?70% with standard deviations (SD)?<?15% were obtained for all compounds under the selected conditions. Method detection limits were in the 0.0030.009?mg/kg range. The positive samples were confirmed by gas chromatography coupled with tandem mass spectrometry (GC-MS/MS). The highest percentage found of the OCC in real samples corresponded to HCB, o,p'-DDT and methoxychlor, which were detected in 80 and 95% of samples analyzed respectively. Copyright (c) 2012 John Wiley & Sons, Ltd. | |
dc.language.iso | eng | |
dc.rights | restrictedAccess | |
dc.subject | Análise instrumental, Química | |
dc.subject | Instrumental analysis, Chemical sciences | |
dc.title | Optimization and validation of organochlorine compounds in adipose tissue by SPE-gas chromatography | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Faculdade de Ciências | |
dc.contributor.uporto | Faculdade de Medicina | |
dc.identifier.doi | 10.1002/bmc.2723 | |
dc.identifier.authenticus | P-002-365 | |
dc.subject.fos | Ciências exactas e naturais::Química | |
dc.subject.fos | Natural sciences::Chemical sciences | |
Appears in Collections: | FCUP - Artigo em Revista Científica Internacional FMUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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46898.pdf Restricted Access | 1.14 MB | Adobe PDF | Request a copy from the Author(s) |
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