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Author(s): Nuno Vale
Margaret S Collins
Jiri Gut
Ricardo Ferraz
Philip J Rosenthal
Melanie T Cushionc
Rui Moreira
Paula Gomes
Title: Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
Issue Date: 2008
Abstract: A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 mu g/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the mu M range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead compound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.
Subject: Química
Chemical sciences
Scientific areas: Ciências exactas e naturais::Química
Natural sciences::Chemical sciences
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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