Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/82058
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dc.creatorSantos, C
dc.creatorMateus, ML
dc.creatordos Santos, AP
dc.creatorMoreira, R
dc.creatorde Oliveira, E
dc.creatorGomes, P
dc.date.accessioned2019-02-02T21:30:11Z-
dc.date.available2019-02-02T21:30:11Z-
dc.date.issued2005
dc.identifier.issn0960-894X
dc.identifier.othersigarra:89123
dc.identifier.urihttps://repositorio-aberto.up.pt/handle/10216/82058-
dc.description.abstractDipeptide esters of paracetamol were prepared in high yields. These compounds are quantitatively hydrolyzed to paracetamol and corresponding 2,5-diketopiperazines at pH 7.4 and 37 degrees C. The reactivity is increased in sarcosine and proline peptides and decreased by bulky side chains at both the N- and C-terminal residues of the dipeptide carrier. Moreover, dipeptide esters of paracetamol did not affect the levels of hepatic glutathione. Thus, dipeptides seem promising candidates as carriers for cyclization-activated prodrugs.
dc.language.isoeng
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectQuímica
dc.subjectChemical sciences
dc.titleCyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Ciências
dc.identifier.doi10.1016/j.bmcl.2005.01.065
dc.identifier.authenticusP-000-47T
dc.subject.fosCiências exactas e naturais::Química
dc.subject.fosNatural sciences::Chemical sciences
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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