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DC Field | Value | Language |
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dc.creator | Santos, C | |
dc.creator | Mateus, ML | |
dc.creator | dos Santos, AP | |
dc.creator | Moreira, R | |
dc.creator | de Oliveira, E | |
dc.creator | Gomes, P | |
dc.date.accessioned | 2022-09-07T18:11:17Z | - |
dc.date.available | 2022-09-07T18:11:17Z | - |
dc.date.issued | 2005 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.other | sigarra:89123 | |
dc.identifier.uri | https://hdl.handle.net/10216/82058 | - |
dc.description.abstract | Dipeptide esters of paracetamol were prepared in high yields. These compounds are quantitatively hydrolyzed to paracetamol and corresponding 2,5-diketopiperazines at pH 7.4 and 37 degrees C. The reactivity is increased in sarcosine and proline peptides and decreased by bulky side chains at both the N- and C-terminal residues of the dipeptide carrier. Moreover, dipeptide esters of paracetamol did not affect the levels of hepatic glutathione. Thus, dipeptides seem promising candidates as carriers for cyclization-activated prodrugs. | |
dc.language.iso | eng | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject | Química | |
dc.subject | Chemical sciences | |
dc.title | Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Faculdade de Ciências | |
dc.identifier.doi | 10.1016/j.bmcl.2005.01.065 | |
dc.identifier.authenticus | P-000-47T | |
dc.subject.fos | Ciências exactas e naturais::Química | |
dc.subject.fos | Natural sciences::Chemical sciences | |
Appears in Collections: | FCUP - Artigo em Revista Científica Internacional |
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