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Author(s): Mary K S Batista
Marcal Gallemi
Alberto Adeva
Carlos A R Gomes
Paula Gomes
Title: Facile Regioselective Synthesis of a Novel Chitosan-Pexiganan Conjugate with Potential Interest for the Treatment of Infected Skin Lesions
Issue Date: 2009
Abstract: A pexiganan-chitosan conjugate was designed to combine the exceptional bioadhesion and tissue-regenerating abilities of chitosan with the excellent antibiotic properties of pexiganan. We herein report our first results on the successful synthesis, including Fourier transform infrared (FT-IR) and amino acid analysis of such conjugate, which was prepared by regioselective covalent attachment of a Cys-containing pexiganan analog to the chitosan's amino groups. Further results from ongoing research will be reported.
Subject: Química
Chemical sciences
Scientific areas: Ciências exactas e naturais::Química
Natural sciences::Chemical sciences
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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