Facile Regioselective Synthesis of a Novel Chitosan-Pexiganan Conjugate with Potential Interest for the Treatment of Infected Skin Lesions

Abstract

A pexiganan-chitosan conjugate was designed to combine the exceptional bioadhesion and tissue-regenerating abilities of chitosan with the excellent antibiotic properties of pexiganan. We herein report our first results on the successful synthesis, including Fourier transform infrared (FT-IR) and amino acid analysis of such conjugate, which was prepared by regioselective covalent attachment of a Cys-containing pexiganan analog to the chitosan's amino groups. Further results from ongoing research will be reported.