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https://hdl.handle.net/10216/82027| Author(s): | Bianca Perez Catia Teixeira Ines S Albuquerque Jiri Gut Philip J Rosenthal Miguel Prudencio Paula Gomes |
| Title: | PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity |
| Issue Date: | 2012 |
| Abstract: | Novel primaquine derivatives, obtained by conjugation of the drug's aliphatic amine with different cinnamic acids, resulted in increased in vitro activity, compared to primaquine, against liver-stage malarial parasites. The compounds were non-cytotoxic to human hepatoma cells, suggesting that they are a promising new class of agents for the treatment and prevention of malaria. |
| Subject: | Química Chemical sciences |
| Scientific areas: | Ciências exactas e naturais::Química Natural sciences::Chemical sciences |
| DOI: | 10.1039/c2md20113e |
| URI: | https://repositorio-aberto.up.pt/handle/10216/82027 |
| Document Type: | Artigo em Revista Científica Internacional |
| Rights: | openAccess |
| License: | https://creativecommons.org/licenses/by-nc/4.0/ |
| Appears in Collections: | FCUP - Artigo em Revista Científica Internacional |
This item is licensed under a Creative Commons License
