Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/82027
Author(s): Bianca Perez
Catia Teixeira
Ines S Albuquerque
Jiri Gut
Philip J Rosenthal
Miguel Prudencio
Paula Gomes
Title: PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
Issue Date: 2012
Abstract: Novel primaquine derivatives, obtained by conjugation of the drug's aliphatic amine with different cinnamic acids, resulted in increased in vitro activity, compared to primaquine, against liver-stage malarial parasites. The compounds were non-cytotoxic to human hepatoma cells, suggesting that they are a promising new class of agents for the treatment and prevention of malaria.
Subject: Química
Chemical sciences
Scientific areas: Ciências exactas e naturais::Química
Natural sciences::Chemical sciences
URI: https://repositorio-aberto.up.pt/handle/10216/82027
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by-nc/4.0/
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
89164.pdf163.46 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons