Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/117607
Author(s): Oliveira, B.M.P.M.
Trinchet, R
Otero Espinar, MV
Pinto, Aberto A.
Burroughs, N
Title: Modelling the suppression of autoimmunity after pathogen infection
Issue Date: 2018
Abstract: We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 (IL-2) secretion. We model the suppression of the autoimmune line of T cells after a different line of T cells responded to a pathogen infection. In this paper, we show that if the population of the pathogen responding line of T cells becomes large enough, the competition for IL-2 and the increase in the death rates may lead to a depletion in the concentration of autoimmune T cells. Provided this lasts for a sufficiently long time, the concentration of autoimmune T cells can be brought down to values inside the basin of attraction of the controlled state, and autoimmunity can be suppressed. Copyright © 2018 John Wiley & Sons, Ltd.
Subject: Matemática, Matemática
Mathematics, Mathematics
Scientific areas: Ciências exactas e naturais::Matemática
Natural sciences::Mathematics
URI: https://repositorio-aberto.up.pt/handle/10216/117607
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCNAUP - Artigo em Revista Científica Internacional
FCUP - Artigo em Revista Científica Internacional

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