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Otero Espinar, MV
Pinto, Aberto A.
|Title:||Modelling the suppression of autoimmunity after pathogen infection|
|Abstract:||We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 (IL-2) secretion. We model the suppression of the autoimmune line of T cells after a different line of T cells responded to a pathogen infection. In this paper, we show that if the population of the pathogen responding line of T cells becomes large enough, the competition for IL-2 and the increase in the death rates may lead to a depletion in the concentration of autoimmune T cells. Provided this lasts for a sufficiently long time, the concentration of autoimmune T cells can be brought down to values inside the basin of attraction of the controlled state, and autoimmunity can be suppressed. Copyright © 2018 John Wiley & Sons, Ltd.|
|Scientific areas:||Ciências exactas e naturais::Matemática|
|Document Type:||Artigo em Revista Científica Internacional|
|Appears in Collections:||FCNAUP - Artigo em Revista Científica Internacional|
FCUP - Artigo em Revista Científica Internacional
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