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Author(s): Fernanda M. F. Roleira
Christophe Siquet
Elizabeta Orrù
E. Manuela Garrido
Jorge Garrido
Nuno Milhazes
Gianni Podda
Fátima Paiva Martins
Salette Reis
Rui A. Carvalho
Elisiário J. Tavares da Silva
Fernanda Borges
Title: Lipophilic phenolic antioxidants: Correlation between antioxidant profile, partition coefficients and redox properties
Issue Date: 2010
Abstract: Lipophilic compounds structurally based on caffeic, hydrocaffeic, ferulic and hydroferulic acids were synthesized. Subsequently, their antioxidant activity was evaluated as well as their partition coefficients and redox potentials. The structure-property-activity relationship (SPAR) results revealed the existence of a clear correlation between the redox potentials and the antioxidant activity. In addition, some compounds showed a proper lipophilicity to cross the blood-brain barrier. Their predicted ADME properties are also in accordance with the general requirements for potential CNS drugs. Accordingly, one can propose these phenolic compounds as potential antioxidants for tackling the oxidative status linked to the neurodegenerative processes.
Subject: Química
Chemical sciences
Scientific areas: Ciências exactas e naturais::Química
Natural sciences::Chemical sciences
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCUP - Artigo em Revista Científica Internacional
FEUP - Artigo em Revista Científica Internacional
FFUP - Artigo em Revista Científica Internacional

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