Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/100809
Author(s): | Fernanda M. F. Roleira Christophe Siquet Elizabeta Orrù E. Manuela Garrido Jorge Garrido Nuno Milhazes Gianni Podda Fátima Paiva Martins Salette Reis Rui A. Carvalho Elisiário J. Tavares da Silva Fernanda Borges |
Title: | Lipophilic phenolic antioxidants: Correlation between antioxidant profile, partition coefficients and redox properties |
Issue Date: | 2010 |
Abstract: | Lipophilic compounds structurally based on caffeic, hydrocaffeic, ferulic and hydroferulic acids were synthesized. Subsequently, their antioxidant activity was evaluated as well as their partition coefficients and redox potentials. The structure-property-activity relationship (SPAR) results revealed the existence of a clear correlation between the redox potentials and the antioxidant activity. In addition, some compounds showed a proper lipophilicity to cross the blood-brain barrier. Their predicted ADME properties are also in accordance with the general requirements for potential CNS drugs. Accordingly, one can propose these phenolic compounds as potential antioxidants for tackling the oxidative status linked to the neurodegenerative processes. |
Subject: | Química Chemical sciences |
Scientific areas: | Ciências exactas e naturais::Química Natural sciences::Chemical sciences |
URI: | https://hdl.handle.net/10216/100809 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | FCUP - Artigo em Revista Científica Internacional FEUP - Artigo em Revista Científica Internacional FFUP - Artigo em Revista Científica Internacional |
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