Please use this identifier to cite or link to this item: http://hdl.handle.net/10216/100751
Author(s): N.J. Burroughs
M. Ferreira
B.M.P.M. Oliveira
A. A. Pinto
Title: Autoimmunity arising from bystander proliferation of T cells in an immune response model
Issue Date: 2011
Abstract: We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period.
Description: We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period.
Subject: Matemática
Mathematics
URI: http://hdl.handle.net/10216/100751
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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