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https://hdl.handle.net/10216/98112| Author(s): | Isabel Nieto, MI Carmen Balo, MC Brea, J Caamano, O Fernandez, F Garcia Mera, X Lopez, C Isabel Loza, MI Rodriguez Borges, JE Vidal, B |
| Title: | Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A(2B) receptor antagonists |
| Issue Date: | 2010 |
| Abstract: | A new series of 9-deazaxanthine derivatives with various substituents at the heterocyclic system were synthesized and evaluated for their binding affinities for the four human recombinant adenosine receptors, A(1)-A(3) subtypes. A number of the 9-deazaxanthines derivatives 3a-m showed moderate-to-high affinity for hA(2B) receptors, with compound 3f showing a 32-fold selectivity for A(2B) over A(1) and a 2750-fold selectivity for A(2B) over A(2A). |
| Subject: | Química clínica, Neuroquímica, Química orgânica, Engenharia química Clinical chemistry, Neurochemistry, Organic chemistry, Chemical engineering |
| Scientific areas: | Ciências da engenharia e tecnologias::Engenharia química Engineering and technology::Chemical engineering |
| DOI: | 10.1016/j.ejmech.2010.03.011 |
| URI: | https://hdl.handle.net/10216/98112 |
| Document Type: | Artigo em Revista Científica Internacional |
| Rights: | restrictedAccess |
| Appears in Collections: | FCUP - Artigo em Revista Científica Internacional |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 49408.pdf Restricted Access | 502.36 kB | Adobe PDF | View/Open |
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