Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/96094
Author(s): Stefano Alcaro
Alexandra Gaspar
Francesco Ortuso
Nuno Milhazes
Francisco Orallo
Eugenio Uriarte
Matilde Yáñez
Fernanda Borges
Title: Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B
Issue Date: 2010
Abstract: Chromone carboxylic acids were evaluated as human monoamine oxidase A and B (hMAO-A and hMAOB)inhibitors. The biological data indicated that only chromone-3-carboxylic acid is a potent hMAO-Binhibitor, with a high degree of selectivity for hMAO-B compared to hMAO-A. Conversely the chromone-2-carboxylic acid resulted almost inactive against both MAO isoforms. Docking experiments wereperformed to elucidate the reasons of the different MAO IC50 data and to explain the absence of activityversus selectivity, respectively.
Subject: Química orgânica, Engenharia química
Organiz chemistry, Chemical engineering
Scientific areas: Ciências da engenharia e tecnologias::Engenharia química
Engineering and technology::Chemical engineering
URI: https://repositorio-aberto.up.pt/handle/10216/96094
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
48505.pdf
  Restricted Access
264.1 kBAdobe PDF    Request a copy from the Author(s)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.