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https://hdl.handle.net/10216/96094| Author(s): | Stefano Alcaro Alexandra Gaspar Francesco Ortuso Nuno Milhazes Francisco Orallo Eugenio Uriarte Matilde Yáñez Fernanda Borges |
| Title: | Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B |
| Issue Date: | 2010 |
| Abstract: | Chromone carboxylic acids were evaluated as human monoamine oxidase A and B (hMAO-A and hMAOB) inhibitors. The biological data indicated that only chromone-3-carboxylic acid is a potent hMAO-B inhibitor, with a high degree of selectivity for hMAO-B compared to hMAO-A. Conversely the chromone- 2-carboxylic acid resulted almost inactive against both MAO isoforms. Docking experiments were performed to elucidate the reasons of the different MAO IC50 data and to explain the absence of activity versus selectivity, respectively. |
| Subject: | Química orgânica, Engenharia química Organic chemistry, Chemical engineering |
| Scientific areas: | Ciências da engenharia e tecnologias::Engenharia química Engineering and technology::Chemical engineering |
| URI: | https://hdl.handle.net/10216/96094 |
| Document Type: | Artigo em Revista Científica Internacional |
| Rights: | restrictedAccess |
| Appears in Collections: | FCUP - Artigo em Revista Científica Internacional |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 48505.pdf Restricted Access | 264.1 kB | Adobe PDF | View/Open |
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