Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/95481
Author(s): Santos, NC
Costa, P
Ruano, D
MacEdo, A
Soares, MJ
Valente, J
Pereira, AT
Azevedo, MH
Palha, JA
Title: Revisiting thyroid hormones in schizophrenia
Issue Date: 2012
Abstract: Thyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosignaling systems involved in schizophrenia's pathophysiology. These include the serotonergic, dopaminergic, glutamatergic, and GABAergic networks, as well as myelination and inflammatory processes. The available evidence supports that thyroid hormones deregulation is a common feature in schizophrenia and that the implications of thyroid hormones homeostasis in the fine-tuning of crucial brain networks warrants further research. © 2012 Nadine Correia Santos et al.
Subject: Psicologia
Psychology
Scientific areas: Ciências sociais::Psicologia
Social sciences::Psychology
URI: https://repositorio-aberto.up.pt/handle/10216/95481
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FPCEUP - Artigo em Revista Científica Internacional

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