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Author(s): Teresa L. Serafim
Maria P. Marques
Maria Fernanda Borges
Paulo J. Oliveira
Title: Mitochondria as a target for novel chemotherapeutic agents based on phenolic acids
Issue Date: 2010
Abstract: Every day, new molecules with antineoplastic potentialare discovered. Unfortunately, most of these moleculeslack cell-type specificity, and are unable to kill tumorcells any more efficiently than normal cells. Also, a highnumber of those molecules are very toxic. In order todesign more effective chemotherapeutic drugs, it is importantto understand the interaction between novelmolecules and biological systems. Certain cellular componentsare particularly relevant in the context of specifictargeting and mechanisms of action. Mitochondriaare not only the major source of cell energy but are alsoimportant in the control of processes that culminate inapoptotic cell death. Particular aspects of mitochondrialphysiology (e.g. the negative transmembrane electricpotential) facilitate selective targeting by anti-cancermolecules. Such mitochondria-specific drugs are referredto as 'mitocans'. Among potential mitocans, phenolicacids are attractive candidates. Plant-derived phenoliccompounds are widely consumed in a normal diet, especiallyin fruits and vegetables. Besides their antioxidantproperties, phenolic acids have been reported to displayantiproliferative activity by promoting selective inductionof tumor cell apoptosis. In some cases, the molecule actsby triggering the mitochondrial pathway for apoptosis.Here we review the potential role of several phenolicacids and derivatives as anti-cancer agents, highlightingthe role of mitochondria as a primary subcellular targetfor this class of compounds. The present review intends to raise awareness for this promising direction of research.
Subject: Química farmacêutica, Química clínica, Engenharia química
Pharmaceutical chemistry, Clinical chemistry, Chemical engineering
Scientific areas: Ciências da engenharia e tecnologias::Engenharia química
Engineering and technology::Chemical engineering
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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