Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/93094
Author(s): | A. Pelaez-Vargas D. Gallego-Perezc M. Magallanes-Perdomo M. H. Fernandes D.J. Hansfordc H. De Aza P. Pena F. J. Monteiro |
Title: | Isotropic micropatterned silica coatings on zirconia induce guided cell growth for dental implants |
Issue Date: | 2011 |
Abstract: | Titanium implants are the gold standard in dentistry; however, problems such as gingival tarnishing and peri-implantitis have been reported. For zirconia to become a competitive alternative dental implant material, surface modification techniques that induce guided tissue growth must be developed. Objectives: To develop alternative surface modification techniques to promote guided tissue regeneration on zirconia materials, for applications in dental implantology. Methods: A methodology that combined soft lithography and sol-gel chemistry was used to obtain isotropic micropatterned silica coatings on yttria-stabilized zirconia substrates. The materials were characterized via chemical, structural, surface morphology approaches. In vitro biological behavior was evaluated in terms of early adhesion and viability/metabolic activity of human osteoblast-like cells. Statistical analysis was conducted using one-way ANOVA/Tukey HSD post hoc test. Results: Isotropic micropatterned silica coatings on yttria-stabilized zirconia substrates were obtained using a combined approach based on sol-gel technology and soft lithography. Micropatterned silica surfaces exhibited a biocompatible behavior, and modulated cell responses (i.e. inducing early alignment of osteoblast-like cells). After 7 d of culture, the cells fully covered the top surfaces of pillar microstructured silica films. Significance: The micropatterned silica films on zirconia showed a biocompatible response, and were capable of inducing guided osteoblastic cell adhesion, spreading and propagation. The results herein presented suggest that surface-modified ceramic implants via soft lithography and sol-gel chemistry could potentially be used to guide periodontal tissue regeneration, thus promoting tight tissue apposition, and avoiding gingival retraction and peri-implantitis. © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved. |
Subject: | Ciências da Saúde, Outras ciências médicas Health sciences, Other medical sciences |
Scientific areas: | Ciências médicas e da saúde::Outras ciências médicas Medical and Health sciences::Other medical sciences |
URI: | https://repositorio-aberto.up.pt/handle/10216/93094 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | FEUP - Artigo em Revista Científica Internacional FMDUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
78078.pdf Restricted Access | 845.92 kB | Adobe PDF | Request a copy from the Author(s) |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.