Anti-sessile bacterial and cytocompatibility properties of CHX-loaded nanohydroxyapatite

Nanohydroxyapatite possesses exceptional biocompatibility and bioactivity regarding bone cells and tissues, justifying its use as a coating material or as a bone substitute. Unfortunately, this feature may also encourage bacterial adhesion and biofilm formation. Surface functionalization with antimicrobials is a promising strategy to reduce the likelihood of bacterial infestation and colonization on medical devices. Chlorhexidine digluconate is a common and effective antimicrobial agent used ...

Characterisation of the Osteoclastogenic Potential of Human Osteoblastic and Fibroblastic Conditioned Media

Although M-CSF and RANKL are sufficient to promote in vitro osteoclastogenesis, in vivo this is a complex process which requires the action of many signalling molecules and cellular crosstalks. In this work, isolated or combined Conditioned media, obtained from human adult skin fibroblast and bone marrow cells, were tested for their osteoclastogenic potential, through an indirect co-culture system, in the absence of recombinant M-CSF and RANKL Osteoclastogenesis was assessed on human peripher...

Comparative study of the prevalence of occlusal anomalies in Down Syndrome children and their siblings

Efectos de las enfermedades periodontales sobre la diabetes