Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/92945
Author(s): | Burroughs, N.J. Ferreira, M. Oliveira, Bruno Pinto, A.A. |
Title: | Autoimmunity arising from bystander proliferation of T cells in animmune response model |
Issue Date: | 2011 |
Abstract: | We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved. |
Description: | We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved. |
Subject: | Ciências da Saúde, Ciências da saúde Health sciences, Health sciences |
Scientific areas: | Ciências médicas e da saúde::Ciências da saúde Medical and Health sciences::Health sciences |
URI: | https://hdl.handle.net/10216/92945 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | FCNAUP - Artigo em Revista Científica Internacional |
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