Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/92672
Full metadata record
DC FieldValueLanguage
dc.creatorRocha, J.C.
dc.creatorAlmeida, M.F.
dc.creatorCarmona, C.
dc.creatorCardoso, M.L.
dc.creatorBorges, Nuno
dc.creatorSoares, I.
dc.creatorSalcedo, G.
dc.creatorLima, M.R.
dc.creatorAzevedo, I.
dc.creatorvan Spronsen, F.J.
dc.date.accessioned2019-02-01T16:45:26Z-
dc.date.available2019-02-01T16:45:26Z-
dc.date.issued2010
dc.identifier.issn0250-6807
dc.identifier.othersigarra:47490
dc.identifier.urihttps://repositorio-aberto.up.pt/handle/10216/92672-
dc.description.abstractBACKGROUND/AIMS: The neurological sequelae resulting from untreated phenylketonuria are diminished by the success of early introduced and continued dietary treatment. Nowadays, nutritional status is gaining importance in the follow-up of these patients. The aim of this work was to study the relevance of prealbumin concentration as biomarker of protein nutritional status of phenylketonuric patients.METHODS: We collected data from 69 phenylketonuric patients on food intake, blood prealbumin and blood phenylalanine concentrations. Protein insufficiency was defined as prealbumin z-scores below the 5th percentile of reference population. Additionally, we considered a prealbumin concentration of 20 mg/dl as a threshold level.RESULTS: Nine patients (13%) showed signs of protein insufficiency. When the threshold of 20 mg/dl for prealbumin was used, we found 38 patients (55%) with low prealbumin concentrations.CONCLUSION: A significant group presented signs of protein insufficiency either using prealbumin z-scores or prealbumin concentration threshold, especially in milder forms of the disease. The results of this seem to confirm the already described threshold level for prealbumin concentration, suggesting that its measurement may be important for nutritional status evaluation, preventing protein insufficiency in milder forms of phenylketonuria.
dc.language.isoeng
dc.rightsrestrictedAccess
dc.subjectCiências da Saúde, Outras ciências médicas
dc.subjectHealth sciences, Other medical sciences
dc.titleThe use of prealbumin concentration as a biomarker of nutritional status in treated phenylketonuric patients
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Ciências da Nutrição e Alimentação
dc.identifier.authenticusP-003-7MC
dc.subject.fosCiências médicas e da saúde::Outras ciências médicas
dc.subject.fosMedical and Health sciences::Other medical sciences
Appears in Collections:FCNAUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
47490.pdf
  Restricted Access
111.57 kBAdobe PDF    Request a copy from the Author(s)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.