Synthesis of methyl (+/-)-3,5-bis(substitutedmethyl)pyrrolidine-2-carboxylates: a convenient approach to proline-mimetics

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Campo DC	Valor	Idioma
dc.creator	Joana F Ferreira da Costa
dc.creator	Olga Caamano
dc.creator	Franco Fernandez
dc.creator	Xerardo Garcia Mera
dc.creator	Pilar Midon
dc.creator	Jose Enrique Rodriguez Borges
dc.date.accessioned	2023-05-23T23:17:37Z	-
dc.date.available	2023-05-23T23:17:37Z	-
dc.date.issued	2010
dc.identifier.issn	0040-4020
dc.identifier.other	sigarra:49301
dc.identifier.uri	https://hdl.handle.net/10216/92589	-
dc.description.abstract	Starting from readily available N-benzyl protected methyl 3,5-bis(hydroxymethyl)pirrolidinecarboxylate a number of racemic methyl t-3,t-5-disubstitutedprolinates have been synthesised, thus opening a practical way towards the preparation of a variety of putative proline-mimetics. In this context, N-Boc protected derivatives proved to be better intermediates than their N-benzyl counterparts in terms of cleanness and overall yield of the synthetic procedure.
dc.language.iso	eng
dc.rights	restrictedAccess
dc.subject	Química
dc.subject	Chemical sciences
dc.title	Synthesis of methyl (+/-)-3,5-bis(substitutedmethyl)pyrrolidine-2-carboxylates: a convenient approach to proline-mimetics
dc.type	Artigo em Revista Científica Internacional
dc.contributor.uporto	Faculdade de Ciências
dc.identifier.doi	10.1016/j.tet.2010.06.053
dc.identifier.authenticus	P-003-3Y8
dc.subject.fos	Ciências exactas e naturais::Química
dc.subject.fos	Natural sciences::Chemical sciences
Aparece nas coleções:	FCUP - Artigo em Revista Científica Internacional

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