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Author(s): Burroughs, N.J.
Oliveira, Bruno
Pinto, Alberto Adrego
Sequeira, H.J.
Title: Sensibility of the quorum growth thresholds controlling local immune responses.
Issue Date: 2008
Abstract: The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.Keywords: Immunology; Tregs; Cytokines; Secretion inhibition; Growth model; Quorum threshold; ODE model.
Subject: Imunologia, Matemática aplicada, Matemática
Immunology, Applied mathematics, Mathematics
Scientific areas: Ciências exactas e naturais::Matemática
Natural sciences::Mathematics
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCNAUP - Artigo em Revista Científica Internacional

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