Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/92334
Author(s): | Burroughs, N.J. Oliveira, Bruno Pinto, Alberto Adrego Sequeira, H.J. |
Title: | Sensibility of the quorum growth thresholds controlling local immune responses |
Issue Date: | 2008 |
Abstract: | The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs. |
Subject: | Imunologia, Matemática aplicada, Matemática Immunology, Applied mathematics, Mathematics |
Scientific areas: | Ciências exactas e naturais::Matemática Natural sciences::Mathematics |
URI: | https://hdl.handle.net/10216/92334 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | FCNAUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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47220.pdf Restricted Access | 1.76 MB | Adobe PDF | Request a copy from the Author(s) |
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