Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/91796
Author(s): N. J. Burroughs
B. M. P. M. Oliveira
A. A. Pinto
H. J. T. Sequeira,
Title: Sensibility of the quorum growth thresholds controlling local immune responsesQ
Issue Date: 2008
Abstract: The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling.We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immuneresponses develop on activation and whether the immune system returns to a control state. We study the effects in the quorumT cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the valueof the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.
Description: The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling.We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immuneresponses develop on activation and whether the immune system returns to a control state. We study the effects in the quorumT cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the valueof the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.
Subject: Matemática, Matemática
Mathematics, Mathematics
Scientific areas: Ciências exactas e naturais::Matemática
Natural sciences::Mathematics
URI: https://repositorio-aberto.up.pt/handle/10216/91796
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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