Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/91796
Author(s): | N. J. Burroughs B. M. P. M. Oliveira A. A. Pinto H. J. T. Sequeira, |
Title: | Sensibility of the quorum growth thresholds controlling local immune responses Q |
Issue Date: | 2008 |
Abstract: | The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs. |
Description: | The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs. |
Subject: | Matemática, Matemática Mathematics, Mathematics |
Scientific areas: | Ciências exactas e naturais::Matemática Natural sciences::Mathematics |
URI: | https://hdl.handle.net/10216/91796 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | FCUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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48357.pdf Restricted Access | 1.76 MB | Adobe PDF | Request a copy from the Author(s) |
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