Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/90545
Author(s): Ricardo Jorge Dinis Oliveira
Title: Oxidative and Non-Oxidative Metabolomics of Ethanol
Issue Date: 2016
Abstract: Background: It is well known that ethanol can cause significant morbidity and mortality, and much of the related toxic effects can be explained by its metabolic profile. Objective: This work performs a complete review of the metabolism of ethanol focusing on both major and minor metabolites. Method: An exhaustive literature search was carried out using textual and structural queries for ethanol and related known metabolizing enzymes and metabolites. Results: The main pathway of metabolism is catalyzed by cytosolic alcohol dehydrogenase, which exhibits multiple isoenzymes and genetic polymorphisms with clinical and forensic implications. Another two oxidative routes, the highly inducible CYP2E1 system and peroxisomal catalase may acquire relevance under specific circumstances. In addition to oxidative metabolism, ethanol also originates minor metabolites such as ethyl glucuronide, ethyl sulfate, ethyl phosphate, ethyl nitrite, phosphatidylethanol and fatty acid ethyl esters. These metabolites represent alternative biomarkers since they can be detected several hours or days after ethanol exposure. Conclusion: It is expected that knowing the metabolomics of ethanol may provide additional insights to better understand the toxicological effects and the variability of dose response.
URI: https://repositorio-aberto.up.pt/handle/10216/90545
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FMUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
143345.pdf476.43 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.