Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/82082
Author(s): Vale Costa, S
Costa Gouveia, J
Perez, B
Silva, T
Teixeira, C
Gomes, P
Gomes, MS
Title: N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
Issue Date: 2013
Abstract: A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.
Subject: Medicina básica
Basic medicine
Scientific areas: Ciências médicas e da saúde::Medicina básica
Medical and Health sciences::Basic medicine
URI: https://repositorio-aberto.up.pt/handle/10216/82082
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by-nc/4.0/
Appears in Collections:FCUP - Artigo em Revista Científica Internacional
ICBAS - Artigo em Revista Científica Internacional

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