Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/82077
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dc.creatorEduardo F Marques
dc.creatorRodrigo O Brito
dc.creatorSandra G Silva
dc.creatorEnrique E Rodriguez Borges
dc.creatorMaria Luisa do Vale
dc.creatorPaula Gomes
dc.creatorMaria J Araujo
dc.creatorOlle Soderman
dc.date.accessioned2022-09-07T13:34:44Z-
dc.date.available2022-09-07T13:34:44Z-
dc.date.issued2008
dc.identifier.issn0743-7463
dc.identifier.othersigarra:89155
dc.identifier.urihttps://hdl.handle.net/10216/82077-
dc.description.abstractThe use of amino acids for the synthesis of novel surfactants with vesicle-forming properties potentially enhances the biocompatibility levels needed for a viable alternative to conventional lipid vesicles. In this work, the formation and characterization of catanionic vesicles by newly synthesized lysine- and serine-derived surfactants have been investigated by means of phase behavior mapping and PFG-NMR diffusometry and cryo-TEM methods. The lysine-derived surfactants are double-chained anionic molecules bearing a pseudogemini configuration, whereas the serine-derived amphiphile is cationic and single-chained. Vesicles form in the cationic-rich side for narrow mixing ratios of the two amphiphiles. Two pairs of systems were studied: one symmetric with equal chain lengths, 2C(12)/C(12), and the other highly asymmetric with 2C(8)/C(16) chains, where the serine-based surfactant has the longest chain. Different mechanisms of the vesicle-to-micelle transition were found, depending on symmetry: the 2C12/C12 system entails limited micellar growth and intermediate phase separation, whereas the 2C(8)/C(16) system shows a continuous transition involving large wormlike micelles. The results are interpreted on the basis of currently available models for the micelle-vesicle transitions and the stabilization of catanionic vesicles (energy of curvature vs mixing entropy).
dc.language.isoeng
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectEngenharia dos materiais
dc.subjectMaterials engineering
dc.titleSpontaneous vesicle formation in catanionic mixtures of amino acid-based surfactants: Chain length symmetry effects
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Ciências
dc.identifier.doi10.1021/la801518h
dc.identifier.authenticusP-003-VJF
dc.subject.fosCiências da engenharia e tecnologias::Engenharia dos materiais
dc.subject.fosEngineering and technology::Materials engineering
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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