Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/82048
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dc.creatorGomes, P
dc.creatorGomes, JRB
dc.creatorRodrigues, M
dc.creatorMoreira, R
dc.date.accessioned2019-02-06T12:56:29Z-
dc.date.available2019-02-06T12:56:29Z-
dc.date.issued2003
dc.identifier.issn0040-4020
dc.identifier.othersigarra:89135
dc.identifier.urihttps://repositorio-aberto.up.pt/handle/10216/82048-
dc.description.abstractAcylation of antimalarial and bacteriostatic sulfonamides with N-protected amino acids and peptides was carried out using standard peptide coupling methods. These acylation reactions are regioselective for the N-4 nitrogen atom of diazine-containing sulfonamides. In contrast, only N-1 coupling was found for sulfisoxazole, an isoxazole-based sulfonamide. Computational studies suggest that a combination of geometrical, thermodynamic and electronic factors are responsible for the different reactivities reported.
dc.language.isoeng
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectQuímica
dc.subjectChemical sciences
dc.titleAmino acids as selective sulfonamide acylating agents
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Ciências
dc.identifier.doi10.1016/s0040-4020(03)01206-7
dc.identifier.authenticusP-000-F5Q
dc.subject.fosCiências exactas e naturais::Química
dc.subject.fosNatural sciences::Chemical sciences
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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