Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/82037
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dc.creatorGomes, P
dc.creatorSantos, MI
dc.creatorTrigo, MJ
dc.creatorCastanheiro, R
dc.creatorMoreira, R
dc.date.accessioned2019-02-04T00:41:16Z-
dc.date.available2019-02-04T00:41:16Z-
dc.date.issued2003
dc.identifier.issn0039-7911
dc.identifier.othersigarra:89137
dc.identifier.urihttps://repositorio-aberto.up.pt/handle/10216/82037-
dc.description.abstractPeptide chloromethyl esters are important compounds in prodrug synthesis. A simple, mild and efficient method for the synthesis of chloromethyl esters of N-blocked amino acids and dipeptides using exclusively bromochloromethane is reported. These N-blocked amino acid and dipeptide chloromethyl esters react readily with the carboxylic acid group of aspirin and with the sulfonamido group of the antimalarial sulfamethazine, to give the corresponding prodrugs.
dc.language.isoeng
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectQuímica
dc.subjectChemical sciences
dc.titleImproved synthesis of amino acid and dipeptide chloromethyl esters using bromochloromethane
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Ciências
dc.identifier.doi10.1081/scc-120018930
dc.identifier.authenticusP-000-KNZ
dc.subject.fosCiências exactas e naturais::Química
dc.subject.fosNatural sciences::Chemical sciences
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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