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Author(s): Iva Fernandes
Nuno Vale
Victor de Freitas
Rui Moreira
Nuno Mateus
Paula Gomes
Title: Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
Issue Date: 2009
Abstract: The growth inhibitory activity of imidazoquines, antimalarial imidazolidin-4-ones derived from primaquine, on human cancer cell lines HT-29, Caco-2, and MCF-7 has been evaluated. Primaquine, N-dipeptidyl-primaquine derivatives, and other quinolines have been included in the study for comparison purposes. Primaquine and some of its derivatives were significantly active against the MCF-7 human breast cancer cell line, so these compounds might represent useful leads targeted at the development of novel specific agents against breast cancer. Conversely, all compounds were generally inactive against HT-29, with only one of the imidazoquines having IC(50) below 50 mu M. Activities against the Caco-2 cell line were modest and did not follow any defined trend.
Subject: Ciências médicas e da saúde
Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FCUP - Artigo em Revista Científica Internacional

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