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Author(s): André Vieira
António Torres Marques
Rui Miranda Guedes
Volnei Tita
Title: 4D Numerical Analysis of Scaffolds: A New Approach
Issue Date: 2014
Abstract: A large range of biodegradable polymers are used to produce scaffoldsfor tissue engineering, which temporarily replace the biomechanical functions ofa biologic tissue while it progressively regenerates its capacities. However, the mechanicalbehavior of biodegradable materials during its degradation, which is an importantaspect of the scaffold design, is still an unexplored subject. For a biodegradablescaffold, performance will decrease along its degradation, ideally in accordanceto the regeneration of the biologic tissue, avoiding the stress shielding effect or thepremature rupture. In this chapter, a new numerical approach to predict the mechanicalbehavior of complex 3D scaffolds during degradation time (the 4th dimension)is presented. The degradation of mechanical properties should ideally be compatibleto the tissue regeneration. With this new approach, an iterative process of optimizationis possible to achieve an ideal solution in terms of mechanical behavior anddegradation time. The scaffold can therefore be pre-validated in terms of functionalcompatibility. An example of application of this approach is demonstrated at the endof this chapter.
Subject: Engenharia biomédica, Engenharia médica
Biomedical enginnering, Medical engineering
Scientific areas: Ciências da engenharia e tecnologias::Engenharia médica
Engineering and technology::Medical engineering
Source: Tissue Engineering
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/PTDC/EME-PME/114808/2009/Desenvolvimeto de Reforços para tecidos ligamentosos com fibras compósitas biodegradáveis de PCL/PLA/COMP_BIO
Document Type: Capítulo ou Parte de Livro
Rights: openAccess
Appears in Collections:FEUP - Capítulo ou Parte de Livro

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