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dc.creatorAndré Vieira
dc.creatorAntónio Torres Marques
dc.creatorRui Miranda Guedes
dc.creatorVolnei Tita
dc.description.abstractA large range of biodegradable polymers are used to produce scaffoldsfor tissue engineering, which temporarily replace the biomechanical functions ofa biologic tissue while it progressively regenerates its capacities. However, the mechanicalbehavior of biodegradable materials during its degradation, which is an importantaspect of the scaffold design, is still an unexplored subject. For a biodegradablescaffold, performance will decrease along its degradation, ideally in accordanceto the regeneration of the biologic tissue, avoiding the stress shielding effect or thepremature rupture. In this chapter, a new numerical approach to predict the mechanicalbehavior of complex 3D scaffolds during degradation time (the 4th dimension)is presented. The degradation of mechanical properties should ideally be compatibleto the tissue regeneration. With this new approach, an iterative process of optimizationis possible to achieve an ideal solution in terms of mechanical behavior anddegradation time. The scaffold can therefore be pre-validated in terms of functionalcompatibility. An example of application of this approach is demonstrated at the endof this chapter.
dc.relationinfo:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projectos de I&DT em Todos os Domínios Científicos/PTDC/EME-PME/114808/2009/Desenvolvimeto de Reforços para tecidos ligamentosos com fibras compósitas biodegradáveis de PCL/PLA/COMP_BIO
dc.relation.ispartofTissue Engineering
dc.subjectEngenharia biomédica, Engenharia médica
dc.subjectBiomedical enginnering, Medical engineering
dc.title4D Numerical Analysis of Scaffolds: A New Approach
dc.typeCapítulo ou Parte de Livro
dc.contributor.uportoFaculdade de Engenharia
dc.subject.fosCiências da engenharia e tecnologias::Engenharia médica
dc.subject.fosEngineering and technology::Medical engineering
Appears in Collections:FEUP - Capítulo ou Parte de Livro

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