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dc.creatorAna Horta
dc.creatorClaudia Nobrega
dc.creatorPedro Amorim Machado
dc.creatorVitor Coutinho Teixeira
dc.creatorPalmira Barreira Silva
dc.creatorSusana Boavida
dc.creatorPatricio Costa
dc.creatorRui Sarmento Castro
dc.creatorAntonio Gil Castro
dc.creatorMargarida Correia Neves
dc.description.abstractCD4(+) regulatory T cells (Tregs) are essential for the maintenance of the immune system's equilibrium, by dampening the activation of potential auto-reactive T cells and avoiding excessive immune activation. To correctly perform their function, Tregs must be maintained at the right proportion with respect to effector T cells. Since this equilibrium is frequently disrupted in individuals infected with the human immunodeficiency virus (HIV), we hypothesize that its deregulation could hamper immune reconstitution in patients with poor CD4(+) T cell recovery under highly active antiretroviral therapy (HAART). We analysed Tregs percentages amongst CD4(+) T cells in 53 HIV-infected patients under HAART, with suppression of viral replication and distinct levels of immune reconstitution. As controls, 51 healthy individuals were also analysed. We observed that amongst the patients with Nadir values (the lowest CD4(+) T cell counts achieved) <200 cells/mu L, the individuals with high Tregs percentages (>= 10% of total CD4(+) T cells) had the worse CD4(+) T cell reconstitution. In accordance, the well-described direct correlation between the Nadir value and CD4(+) T cell reconstitution is clearly more evident in individuals with high Tregs proportions. Furthermore, we observed a strong negative correlation between Tregs percentages and CD4(+) T cell recovery among immunological non-responder HIV+ individuals. All together, this work shows that high Tregs frequency is an important factor associated with sub-optimal CD4(+) T cell recovery. This is particularly relevant for immunological non-responders with low Nadir values. Our results suggest that the Tregs proportion might be of clinical relevance to define cut-offs for HAART initiation.
dc.titlePoor Immune Reconstitution in HIV-Infected Patients Associates with High Percentage of Regulatory CD4(+) T Cells
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoFaculdade de Psicologia e de Ciências da Educação
dc.subject.fosCiências sociais::Psicologia
dc.subject.fosSocial sciences::Psychology
Appears in Collections:FPCEUP - Artigo em Revista Científica Internacional

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