DSpace Collection:https://hdl.handle.net/10216/56442026-07-10T14:55:04Z2026-07-10T14:55:04ZEffect of Denture Adhesives on the Surface Roughness and Hardness of Denture Base Resins - A Preliminary Studyhttps://hdl.handle.net/10216/1695282026-05-27T06:47:39Z2025-01-01T00:00:00ZTitle: Effect of Denture Adhesives on the Surface Roughness and Hardness of Denture Base Resins - A Preliminary Study2025-01-01T00:00:00ZAI based rehabilitation: the way forward in addressing unmet needs in musculoskeletal diseasehttps://hdl.handle.net/10216/1743282026-05-09T06:10:13Z2026-01-01T00:00:00ZTitle: AI based rehabilitation: the way forward in addressing unmet needs in musculoskeletal disease2026-01-01T00:00:00ZFrom Alginate to Pixel: Comparing the Effect of Two Dental Impression Methods on Children's Anxietyhttps://hdl.handle.net/10216/1742712026-05-06T06:22:14Z2025-01-01T00:00:00ZTitle: From Alginate to Pixel: Comparing the Effect of Two Dental Impression Methods on Children's Anxiety2025-01-01T00:00:00ZAchieving patency in straight canals obturated with Ah Plus Bioceramic sealer: An Ex Vivo Studyhttps://hdl.handle.net/10216/1667692026-03-26T07:36:33Z2025-01-01T00:00:00ZTitle: Achieving patency in straight canals obturated with Ah Plus Bioceramic sealer: An Ex Vivo Study2025-01-01T00:00:00ZOral healthcare in maternal health services: a cross-country comparative analysis in 10 European countrieshttps://hdl.handle.net/10216/1737762026-03-26T07:36:51Z2026-01-01T00:00:00ZTitle: Oral healthcare in maternal health services: a cross-country comparative analysis in 10 European countries2026-01-01T00:00:00ZBotulinum Toxin Effects on Biochemical Biomarkers Related to Inflammation-Associated Head and Neck Chronic Conditions: A Systematic Review of Preclinical Researchhttps://hdl.handle.net/10216/1722722026-01-20T07:38:33Z2025-01-01T00:00:00ZTitle: Botulinum Toxin Effects on Biochemical Biomarkers Related to Inflammation-Associated Head and Neck Chronic Conditions: A Systematic Review of Preclinical Research2025-01-01T00:00:00ZThe Graduating European Dentist Curriculum Framework:A Multi-Stakeholder Viewhttps://hdl.handle.net/10216/1721672026-01-17T07:34:33Z2025-01-01T00:00:00ZTitle: The Graduating European Dentist Curriculum Framework:A Multi-Stakeholder View2025-01-01T00:00:00ZBotulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions: a systematic review of clinical researchhttps://hdl.handle.net/10216/1721542026-01-17T07:32:42Z2025-01-01T00:00:00ZTitle: Botulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions: a systematic review of clinical research2025-01-01T00:00:00ZExploring Additive Manufacturing for Sports Mouthguards: A Pilot Studyhttps://hdl.handle.net/10216/1721022026-01-18T07:34:13Z2026-01-01T00:00:00ZTitle: Exploring Additive Manufacturing for Sports Mouthguards: A Pilot Study2026-01-01T00:00:00ZIn Vitro Evaluation of the Antimicrobial Properties of Chitosan - Vancomycin Coatings on Grade 4 Titanium Discs: A Preliminary Studyhttps://hdl.handle.net/10216/1720872026-01-15T07:31:47Z2026-01-01T00:00:00ZTitle: In Vitro Evaluation of the Antimicrobial Properties of Chitosan - Vancomycin Coatings on Grade 4 Titanium Discs: A Preliminary Study2026-01-01T00:00:00ZMaxillary Sinus Augmentation with Xenogenic Collagen-Retained Heterologous Cortico-Cancellous Bone: A 3-Year Follow-Up Randomized Controlled Trialhttps://hdl.handle.net/10216/1572122026-01-14T07:21:56Z2024-01-01T00:00:00ZTitle: Maxillary Sinus Augmentation with Xenogenic Collagen-Retained Heterologous Cortico-Cancellous Bone: A 3-Year Follow-Up Randomized Controlled Trial2024-01-01T00:00:00ZEvidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice on telerehabilitation. The European PRM position (UEMS PRM Section)https://hdl.handle.net/10216/1708522025-12-11T07:18:31Z2024-01-01T00:00:00ZTitle: Evidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice on telerehabilitation. The European PRM position (UEMS PRM Section)2024-01-01T00:00:00ZImportance of good hosting: reviewing the bi-directionality of the microbiome-gut-brain-axishttps://hdl.handle.net/10216/1652122025-12-19T07:18:27Z2024-01-01T00:00:00ZTitle: Importance of good hosting: reviewing the bi-directionality of the microbiome-gut-brain-axis2024-01-01T00:00:00ZPressing Issues for Oral Health Care Access and Quality Improvement During Pregnancyin Portugal - A Qualitative Studyhttps://hdl.handle.net/10216/1701202025-11-01T07:20:21Z2025-01-01T00:00:00ZTitle: Pressing Issues for Oral Health Care Access and Quality Improvement During Pregnancyin Portugal - A Qualitative Study2025-01-01T00:00:00ZOral health practices and determinants among university students - A cross-sectional study = Práticas e determinantes de saúde oral entre estudantes universitários - um estudo transversalhttps://hdl.handle.net/10216/1698302025-10-21T06:19:02Z2025-01-01T00:00:00ZTitle: Oral health practices and determinants among university students - A cross-sectional study = Práticas e determinantes de saúde oral entre estudantes universitários - um estudo transversal2025-01-01T00:00:00ZComparison of Modulation-Assisted Machining Strategies for Achieving Chip Breakage When Turning 17-4 PH Stainless Steelhttps://hdl.handle.net/10216/1670432025-06-13T06:23:42Z2024-01-01T00:00:00ZTitle: Comparison of Modulation-Assisted Machining Strategies for Achieving Chip Breakage When Turning 17-4 PH Stainless Steel2024-01-01T00:00:00ZBone regeneration driven by a nano-hydroxyapatite/chitosan composite bioaerogel for periodontal regenerationhttps://hdl.handle.net/10216/1626892025-06-06T06:21:33Z2024-01-01T00:00:00ZTitle: Bone regeneration driven by a nano-hydroxyapatite/chitosan composite bioaerogel for periodontal regeneration
Abstract: The most recent progress in reconstructive therapy for the management of periodontitis and peri-implantitis bone defects has relied on the development of highly porous biodegradable bioaerogels for guided bone regeneration. The objective of this work was to evaluate in vitro the osteoinduction of periodontal-originating cells (human dental follicle mesenchymal cells, DFMSCs) promoted by a nano-hydroxyapatite/chitosan (nHAp/CS) bioaerogel, which was purified and sterilized by a sustainable technique (supercritical CO2). Moreover, the in vivo bone regeneration capacity of the nHAp/CS bioaerogel was preliminarily assessed as a proof-of-concept on a rat calvaria bone defect model. The quantification of DNA content of DFMSCs seeded upon nHAp/CS and CS scaffolds (control material) showed a significant increase from the 14th to the 21st day of culture. These results were corroborated through confocal laser scanning microscopy analysis (CLSM). Furthermore, the alkaline phosphatase (ALP) activity increased significantly on the 21st day, similarly for both materials. Moreover, the presence of nHAp promoted a significantly higher expression of osteogenic genes after 21 days when compared to CS scaffolds and control. CLSM images of 21 days of culture also showed an increased deposition of OPN over the nHAp/CS surface. The in vivo bone formation was assessed by microCT and histological analysis. The in vivo evaluation showed a significant increase in bone volume in the nHAp/CS test group when compared to CS and the empty control, as well as higher new bone formation and calcium deposition within the nHAp/CS structure. Overall, the present study showed that the nHAp/CS bioaerogel could offer a potential solution for periodontal and peri-implant bone regeneration treatments since the in vitro results demonstrated that it provided favorable conditions for DFMSC proliferation and osteogenic differentiation, while the in vivo outcomes confirmed that it promoted higher bone ingrowth.2024-01-01T00:00:00ZNanostructured ZnO thin film to enhance gutta-percha's adhesion to endodontic sealershttps://hdl.handle.net/10216/1656342025-03-06T07:22:31Z2024-01-01T00:00:00ZTitle: Nanostructured ZnO thin film to enhance gutta-percha's adhesion to endodontic sealers2024-01-01T00:00:00ZDirect vs. Indirect Digital Implant Impressions: A Time and Cost Analysishttps://hdl.handle.net/10216/1656302025-03-06T07:23:05Z2024-01-01T00:00:00ZTitle: Direct vs. Indirect Digital Implant Impressions: A Time and Cost Analysis2024-01-01T00:00:00ZChitosan's Ability to Remove the Smear Layer-A Systematic Review of Ex Vivo Studieshttps://hdl.handle.net/10216/1656242025-03-06T07:22:45Z2025-01-01T00:00:00ZTitle: Chitosan's Ability to Remove the Smear Layer-A Systematic Review of Ex Vivo Studies2025-01-01T00:00:00Z