Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/1906
Author(s): Maria Maia
Mónica Rodrigues
Paula Serrão
Manuel Pestana
Title: Jejunal dopamine and Na+,K+-ATPase activity in nephrotic syndrome
Issue Date: 2005
Abstract: Background: The occurrence of complementary functions in sodium transport between the intestine and the kidney was suggested to occur when the renal function is immature or compromised and jejunal dopamine has been implicated in this renal-intestinal cross-talk. The jejunal sodium transport was not previously evaluated in the nephrotic syndrome. Methods: We examined the jejunal Na+,K+-ATPase activity and the role of dopamine in puromycin aminonucleoside (PAN) and HgCl2-induced nephrotic syndrome rat models. Results: In both nephrotic syndrome rat models, the jejunal Na+,K+-ATPase activity was reduced during greatest sodium retention and ascites accumulation (PAN nephrosis, day 7; HgCl2 nephrosis, day 14), whereas during enhanced sodium excretion and ascites mobilization the jejunal Na+,K+-ATPase activity was increased in IHgCl2 nephrosis (day 21) land was similar to controls in PAN nephrosis (day 14). In both PAN- and HgCl2-induced nephrosis, the jejunal aromatic L-amino acid decarboxylase (AADC) activity,the enzyme responsible for the synthesis of jejunal dopamine, did not differ from controls. In addition, the jejunal Na+,K+-ATPase activity was not sensitive to inhibition by dopamine (1 mu M) in both experimental groups throughout the study. Conclusions: In the nephrotic syndrome the jejunal Na+,K+-ATPase activity may respond in a compensatory way to changes in extracellular volume, through dopamine-independent mechanisms. Copyright (C) 2005 S, Karger AG, Basel.
Subject: Ciências da Saúde
Health sciences
URI: https://repositorio-aberto.up.pt/handle/10216/1906
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by-nc/4.0/
Appears in Collections:FMDUP - Artigo em Revista Científica Internacional
FMUP - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
79385.pdf207.52 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons