Cardiotoxicidade associada à terapêutica oncológica: mecanismos fisiopatológicos e estratégias de prevenção

Cardiotoxicity is one of the most significant adverse effects of cancer treatment, and is responsible for considerable morbidity and mortality. Among the effects of chemotherapeutic agents on the cardiovascular system, the most frequent and serious is heart failure with ventricular systolic dysfunction. Other toxic effects include hypertension, thromboembolic disease, pericardial disease, arrhythmias and myocardial ischemia. For several decades, cancer therapy-induced cardiomyopathy was almos...

Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer Activity by Applying the Heavy-Atom Effect

Photodynamic therapy (PDT) is an anticancer therapeutic modality with remarkable advantages over more conventional approaches. However, PDT is greatly limited by its dependence on external light sources. Given this, PDT would benefit from new systems capable of a light-free and intracellular photodynamic effect. Herein, we evaluated the heavy-atom effect as a strategy to provide anticancer activity to derivatives of coelenterazine, a chemiluminescent single-molecule widespread in marine organ...

Identifying HEXACO personality types: what do type characteristics tell us about student misconduct?

Background While previous research has largely focused on individual trait associations with academic misbehaviour, this study used a person-centred approach to explore personality type differences in student misconduct. The distribution of the personality types was also compared across sociodemographic groups and fields of study. Methods A sample of 1,398 health and non-health university students replied to a multiple-choice questionnaire covering HEXACO personality traits, eight forms of ac...

Beyond Healing: The Transformative Role of Customer Experience in Healthcare and Its Contribution to Patient Well-Being

Customer Experience (CX) and transformative service research (TSR) are current academic priorities. Healthcare is a prime example of a service inherently transformative, with patient experience (PX) playing a critical role. However, the literature lacks a comprehensive understanding of PX and its effects on patients' well-being. To bridge this research gap, semi-structured interviews were conducted, involving healthcare managers, providers and patients, revealing nine key dimensions of PX, cr...