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  <title>DSpace Collection:</title>
  <link rel="alternate" href="https://hdl.handle.net/10216/1883" />
  <subtitle />
  <id>https://hdl.handle.net/10216/1883</id>
  <updated>2026-07-10T14:41:40Z</updated>
  <dc:date>2026-07-10T14:41:40Z</dc:date>
  <entry>
    <title>Identifying HEXACO personality types: what do type characteristics tell us about student misconduct?</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/173416" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/173416</id>
    <updated>2026-04-30T06:36:38Z</updated>
    <published>2025-01-01T00:00:00Z</published>
    <summary type="text">Title: Identifying HEXACO personality types: what do type characteristics tell us about student misconduct?
Abstract: Background While previous research has largely focused on individual trait associations with academic misbehaviour, this study used a person-centred approach to explore personality type differences in student misconduct. The distribution of the personality types was also compared across sociodemographic groups and fields of study. Methods A sample of 1,398 health and non-health university students replied to a multiple-choice questionnaire covering HEXACO personality traits, eight forms of academic misconduct, and background information. Personality types were explored through cluster analysis, and differences in their behaviour and characteristics were examined using chi-square test and ANOVA. Results The five personality types identified differed in their self-reported academic misconduct. Risk-takers disclosed the highest levels of misconduct, followed by Performance-oriented students, who had competitive dispositions. Secure and Socially Considerate students exhibited more well-adjusted and prosocial traits, respectively, disclosing the lowest rates of misconduct. Insecure students scored higher than these two types on Plagiarism, combining traits associated with psychological distress that may affect their performance. The personality types also revealed gender and socioeconomic differences, and a more uniform distribution in health than in non-health fields. Conclusion This study expands on past research by analysing a distinct set of personality types in association with academic misconduct. Understanding the psychosocial characteristics and field of study distribution of these types helped to propose tailored educational strategies to foster their compliance with academic integrity.</summary>
    <dc:date>2025-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Beyond Healing: The Transformative Role of Customer Experience in Healthcare and Its Contribution to Patient Well-Being</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/171706" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/171706</id>
    <updated>2026-03-22T07:48:29Z</updated>
    <published>2025-01-01T00:00:00Z</published>
    <summary type="text">Title: Beyond Healing: The Transformative Role of Customer Experience in Healthcare and Its Contribution to Patient Well-Being
Abstract: Customer Experience (CX) and transformative service research (TSR) are current academic priorities. Healthcare is a prime example of a service inherently transformative, with patient experience (PX) playing a critical role. However, the literature lacks a comprehensive understanding of PX and its effects on patients' well-being. To bridge this research gap, semi-structured interviews were conducted, involving healthcare managers, providers and patients, revealing nine key dimensions of PX, critical to patients' well-being. This study advances CX literature and TSR by proposing a conceptual framework on PX and its transformative effects, while offering managerial insights for improving well-being and experiences in healthcare.</summary>
    <dc:date>2025-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>3D vocal tract reconstruction using magnetic resonance imaging data to study fricative consonant production</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/78476" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/78476</id>
    <updated>2026-03-21T07:45:42Z</updated>
    <published>2015-01-01T00:00:00Z</published>
    <summary type="text">Title: 3D vocal tract reconstruction using magnetic resonance imaging data to study fricative consonant production
Abstract: The development of Magnetic Resonance Imaging (MRI) has grown rapidly in clinical practice. Currently, the use of MRI in speech research provides useful and accurate qualitative and quantitative data of speech articulation. The aim of this work was to describe an effective method to extract vocal tract and compute their volumes during speech production from MRI images. Using a 3.0 Tesla MRI system, 2D and 3D images of the vocal tract were collected and used to analyze the vocal tract during the production of fricative consonants. These images were also used to build the associated 3D models and compute their volumes. This approach showed that, in general, the volumes measured for the voiceless consonants are smaller than the counterpart voiced consonants. (c) Springer International Publishing Switzerland 2015.</summary>
    <dc:date>2015-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Patient-Specific Study of a Stenosed Carotid Artery Bifurcation Using Fluid-Structure Interactive Simulation</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/113675" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/113675</id>
    <updated>2026-03-21T07:44:39Z</updated>
    <published>2018-01-01T00:00:00Z</published>
    <summary type="text">Title: Patient-Specific Study of a Stenosed Carotid Artery Bifurcation Using Fluid-Structure Interactive Simulation
Abstract: Atherosclerosis at the carotid bifurcation is a major risk factor for stroke. A computational model incorporating transient wall deformation of carotid arteries was developed to assess the influence of artery compliance on wall shear stress (WSS). Clinical data was obtained from ultrasound technique. Two patients were studied, one presenting a mild-graded carotid stenosis along internal carotid artery (ICA) and the other with no visible stenosis. It is hoped that patient-specific biomechanical analyses will help diagnosis and to assess the rupture potential for any particular lesion.</summary>
    <dc:date>2018-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Emotional, inflammatory, and genetic factors of resilience and vulnerability to depression in patients with premenopausal breast cancer: a longitudinal study protocol</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/148275" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/148275</id>
    <updated>2026-03-20T07:44:52Z</updated>
    <published>2023-01-01T00:00:00Z</published>
    <summary type="text">Title: Emotional, inflammatory, and genetic factors of resilience and vulnerability to depression in patients with premenopausal breast cancer: a longitudinal study protocol</summary>
    <dc:date>2023-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Relationship between social support and psychological symptoms in people living with HIV/AIDS, at risk of developing HIV - associated dementia</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/172987" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/172987</id>
    <updated>2026-03-19T07:46:43Z</updated>
    <published>2025-01-01T00:00:00Z</published>
    <summary type="text">Title: Relationship between social support and psychological symptoms in people living with HIV/AIDS, at risk of developing HIV - associated dementia</summary>
    <dc:date>2025-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Accuracy of Assessing Weight Status in Adults by Structured Observation</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/151207" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/151207</id>
    <updated>2026-03-18T07:36:44Z</updated>
    <published>2023-01-01T00:00:00Z</published>
    <summary type="text">Title: Accuracy of Assessing Weight Status in Adults by Structured Observation
Abstract: &lt;jats:p&gt;The assessment of weight status is important in many epidemiological studies, but its direct measurement is not always possible. Self-reported weight and height are often used, although previous research reported low accuracy. This study aimed to test the ability of trained observers to accurately estimate weight status in adults using structured observation. A cross-sectional study was conducted. For each participant, height and weight were estimated in categories, and weight status was recorded using Stunkards body figures, by two trained observers. Height and weight were also measured, using standardized procedures. Subjects were classified according to World Health Organization body mass index (BMI) cut-offs from objective measurements and from the BMI assigned to each body figure. Sensitivity, specificity, and likelihood ratios were calculated to assess the accuracy of estimating weight status by observation. Kappa was used to test inter-observer reliability. A total of 127 participants were assessed, 70 women and 57 men, aged between 19 and 89 years (mean ± standard deviation: 50.3 ± 16.3 years). Most participants were overweight or obese (64.3% women; 78.9% men). The sensitivity and specificity of overweight/obesity status identification were 72.8% and 78.4%, respectively. Observers gender, participants gender, and participants age were significantly associated with the estimation of overweight/obesity. The agreement between observers was moderate for BMI estimates ( = 0.52) but substantial when distinguishing normal weight from overweight/obesity ( = 0.67). Trained observers were able to distinguish normal weight from overweight/obesity with high sensitivity and specificity, and substantial interrater reliability. This innovative methodology showed potential for improvement through enhanced training techniques. The use of structured observation may be a useful and accurate alternative to self-reported weight status assessment, whenever anthropometric measurement is not achievable.&lt;/jats:p&gt;</summary>
    <dc:date>2023-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Street food in Maputo, Mozambique: Availability and nutritional value of homemade foods</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/118069" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/118069</id>
    <updated>2026-03-17T07:45:31Z</updated>
    <published>2018-01-01T00:00:00Z</published>
    <summary type="text">Title: Street food in Maputo, Mozambique: Availability and nutritional value of homemade foods
Abstract: Background: A nutrition transition is occurring in the urban areas of developing countries, where street food makes an important contribution to daily food intake. Aim: We aimed to characterise street food offer in Maputo, Mozambique, and to evaluate the nutritional composition of the most common homemade foods. Methods: A cross-sectional study was conducted in 2014. Streets in the surroundings (500 m buffer) of randomly selected public transport stops in KaMpfumu district, Maputo, were canvassed to identify all street food vending sites (n = 968). Information regarding vending site characteristics and the food offered was gathered through interview and observation. Samples (n = 80) of the most common homemade foods were collected for laboratorial analysis. Results: Most street food vending sites identified were stationary (77.4%) and sold exclusively industrial food (51.9%). Frequency of fruit, beverages and food other than fruit was 24.5%, 32.5% and 73.9%, respectively. Fried cakes were the most energy-dense (430 kcal/100 g), and richest in fats (21.0g/100 g) and carbohydrates (53.4 g/100 g). The richest sources of protein were the stewed meat/fish/liver dishes (10.711.6 g/100 g). Fried cakes showed the lowest sodium and potassium content (90 mg/100 g and 81 mg/100 g, respectively) whereas hamburgers exhibited the highest content of those micronutrients (455 mg/100 g and 183 mg/100 g, respectively). Stewed liver dishes presented the highest sodium/potassium ratio (11.95). Fried snacks presented the highest trans-fatty acid content (0.20 g/100 g). Conclusions: Street food in Maputo is abundant and scattered throughout the urban district, exhibiting high variability in the nutritional composition of homemade foods. Public health policies should be targeted to improve the street food offer, promoting nutrient-dense foods and the reduction of added salt. (c) The Author(s) 2018.</summary>
    <dc:date>2018-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Street food in Eastern Europe: a perspective from an urban environment in Moldova</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/130167" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/130167</id>
    <updated>2026-03-17T07:45:08Z</updated>
    <published>2020-01-01T00:00:00Z</published>
    <summary type="text">Title: Street food in Eastern Europe: a perspective from an urban environment in Moldova
Abstract: Street food is popular in Eastern Europe, but its diversity and nutritional value are unknown. This study aimed to characterise the street food environment in Chisinau, Moldova, including the vending sites and vendors, food availability and nutritional composition of foods and beverages. All street food vending sites (single point of sale) located in a 1-km buffer centred on the main public market were systematically selected (n439;n328 participants). Data on vending sites' characteristics (mobility, type of physical set-up and access to electricity), operating periods and food availability were collected. Samples of the most commonly available foods of unknown composition were collected (twenty-eight home-made and twenty-four industrial). Macronutrients, Na and K were quantified through chemical analysis. Fruits, beverages and food other than fruits were available in 2 center dot 5, 74 center dot 3 and 80 center dot 8 % of the vending sites, respectively. Among the latter, 66 center dot 4 % sold only industrial foods (e.g. pretzels, biscuits, wafers, chocolate and ice cream), 21 center dot 5 % only home-made (e.g. savoury and sweet pastries) and 12 center dot 1 % both. Home-made foods presented larger serving sizes and energy/serving (median kJ/serving: 1312 center dot 5v.670 center dot 3,P= 0 center dot 022); industrial foods were more energy-dense (median kJ/100 g: 1797 center dot 0v.1269 center dot 8,P= 0 center dot 002). High SFA,trans-fat and Na contents were found, reaching 10 center dot 9 g/serving, 1 center dot 4 g/serving and 773 center dot 7 mg/serving, respectively. Soft drinks and alcoholic beverages were available in 80 center dot 7 and 42 center dot 0 % of the vending sites selling beverages, respectively. Concluding, industrial snacks and home-made pastries high in Na and unhealthy fat were frequent in Chisinau. Prevention of diet-related diseases in Moldova may benefit from the improvement of the nutritional profile of street food.</summary>
    <dc:date>2020-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Availability and Nutritional Composition of Street Food in Urban Central Asia: Findings From Almaty, Kazakhstan</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/144250" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/144250</id>
    <updated>2026-03-17T07:45:28Z</updated>
    <published>2022-01-01T00:00:00Z</published>
    <summary type="text">Title: Availability and Nutritional Composition of Street Food in Urban Central Asia: Findings From Almaty, Kazakhstan
Abstract: Objective: To describe the availability and nutritional composition of commonly available street foods in Almaty, Kazakhstan. Methods: 384 street food vending sites (in 10 public markets) were assessed; information on vending sites characteristics and food availability and samples of the most commonly available street foods (81 homemade; 40 industrial) were collected for chemical analysis. Results: Fruit, beverages and food other than fruit were available in 1.0%, 47.4% and 92.7% of all vending sites. Homemade food other than fruit (e.g., bread, main dishes, snacks, pastries, sandwiches, and cakes) were available in 63.4% of stationary vending sites, while industrial (e.g., snacks, chocolate, cakes, and cookies) in 45.6% of them. Industrial foods were the most energy-dense [median kcal/100 g: 438.8 vs. 267.2, p &lt; 0.001 (homemade)]. Traditional homemade dishes were high in sodium, reaching 2,248 mg/serving (lagman) and major contributors of protein and fat to energy content (shashlik: 22.8% from protein, 68.3% from fat). Industrial chocolate and homemade cake presented the highest saturated (14.6 g/serving) and trans-fat (3.20 g/serving) contents. Conclusion: These findings advocate for the implementation of health promotion strategies targeted at vendors, consumers and other stakeholders. Copyright (c) 2022 Albuquerque, Lança de Morais, Gelormini, Sousa, Casal, Pinho, Damasceno, Moreira, Breda, Lunet and Padrão.</summary>
    <dc:date>2022-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>The Price of Homemade Street Food in Central Asia and Eastern Europe: Is There a Relation with Its Nutritional Value?</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/137503" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/137503</id>
    <updated>2026-03-17T07:45:27Z</updated>
    <published>2021-01-01T00:00:00Z</published>
    <summary type="text">Title: The Price of Homemade Street Food in Central Asia and Eastern Europe: Is There a Relation with Its Nutritional Value?
Abstract: The aim was to describe the price of homemade street foods in four cities of Central Asia and Eastern Europe and to analyze its association with energy density, macronutrients, sodium and potassium contents. Cross-sectional evaluations of street food vending sites were conducted in Dushanbe, Tajikistan (n = 562), Bishkek, Kyrgyzstan (n = 384), Almaty, Kazakhstan (n = 236) and Chis,inau, Moldova (n = 89) in 2016-2017. Information on the homemade street foods available, including price, was systematically collected; the most commonly available foods (n = 64) were sampled for chemical analysis. Prices were converted to international dollars ($) and expressed as $/serving, $/100 g and $/100 kcal. The median street food price was $1.00/serving, $0.85/100 g and $0.33/100 kcal. Traditional foods were cheaper per 100 g than the westernized ($0.77 vs. $1.00, p = 0.011). For each unit increase in energy density (kcal/g), the homemade street foods were $0.12 cheaper per 100 kcal and $0.11 more expensive per 100 g. The carbohydrate content was negatively associated with price per 100 kcal, while total fat, monounsaturated, saturated and trans-fatty acids content were positively associated with price per 100 g. Energy-dense homemade street foods were the cheapest. Further insight on food preparation might clarify the association between carbohydrates and monounsaturated fatty acids content and street food price.</summary>
    <dc:date>2021-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Macronutrient composition of street food in Central Asia: Bishkek, Kyrgyzstan</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/130152" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/130152</id>
    <updated>2026-03-17T07:45:27Z</updated>
    <published>2020-01-01T00:00:00Z</published>
    <summary type="text">Title: Macronutrient composition of street food in Central Asia: Bishkek, Kyrgyzstan
Abstract: Background: Urban areas in central Asia are currently undergoing nutrition transition. Street food is very popular, but the specific foods available and their nutritional composition are unknown. The aim was to describe the availability and macronutrient composition of street foods in Bishkek, Kyrgyzstan. Results: Trained interviewers collected data on street food vending sites' characteristics and food availability (n = 596). Samples of the most commonly available foods and drinks were collected (n = 80 homemade;n = 40 industrial). Macronutrients were quantified through chemical analysis. Fruit, beverages, and food other than fruit were available in 4.0%, 61.7%, and 81.0% of the vending sites, respectively. Among those selling food other than fruit, 56.5% sold only homemade (e.g., bread, main dishes, snacks, pastries, sandwiches, and cakes), 23.3% both homemade and industrial and 20.2% only industrial foods (e.g., bread, snacks, pastries, cakes, and cookies). Homemade foods presented the highest energy/serving (median kcal/serving: 357 versus 145,p &lt; .001). A high content in saturated and trans-fatty acids was observed in some homemade traditional dishes and snacks, reaching, respectively, 30.2 g/serving and 2.9 g/serving (in homemademanty,a traditional dish). Tea and soft drinks were available in over 50% of the vending sites selling beverages. Conclusion: The high availability of street food in Bishkek highlights its importance for this urban population. Traditional snacks, dishes, and beverages coexist with more westernized products. The variability in energy, macronutrients, and lipid profile of homemade and industrial products reflects heterogeneous culinary practices and ingredients. Policies promoting the availability of healthy foods and ingredients should be implemented.</summary>
    <dc:date>2020-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Nutritional content of the street food purchased in Chisinau, Moldova: Opportunity for policy action</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/138821" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/138821</id>
    <updated>2026-03-17T07:45:23Z</updated>
    <published>2022-01-01T00:00:00Z</published>
    <summary type="text">Title: Nutritional content of the street food purchased in Chisinau, Moldova: Opportunity for policy action</summary>
    <dc:date>2022-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Street food in Dushanbe, Tajikistan: Availability and nutritional value</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/125260" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/125260</id>
    <updated>2026-03-17T07:45:09Z</updated>
    <published>2019-01-01T00:00:00Z</published>
    <summary type="text">Title: Street food in Dushanbe, Tajikistan: Availability and nutritional value
Abstract: Street food is part of the culture in central Asia. Although nourishing foods can be found, unhealthier options are becoming increasingly popular - a marker of nutrition transition. The nutritional composition of street foods in urban settings is, however, unknown. The objective of this study was, thus, to characterise the street food availability in Dushanbe, Tajikistan. A total of 800 street food vending sites in public markets were selected through random and systematic procedures. Trained interviewers collected data on vending sites' characteristics, location and food available. Samples of the most commonly available foods were collected (99 homemade and 35 industrial). Macronutrients were quantified through proximate analysis. Fruit, drinks and foods other than fruit were available, respectively, in 4.5%, 40.5%, and 87.4%, of the vending sites. Among the latter, 63.6% sold only homemade (e.g., bread, traditional dishes, snacks, pastries, sandwiches and cakes), 19.3% only industrial (e.g., bread, snacks, pastries and cookies) and 17.1% both types of food. Homemade foods presented higher energy per serving than industrial foods (median kcal/serving: 452 vs 276, p&lt;0.001). A high content in saturated (soup: 10.9 g/serving) and trans-fatty acids (cakes: 1.8 g/serving) was also found in homemade foods. However, the highest content in these fatty acids was found in industrial wafers (12.9 g/serving and 2.5 g/serving, respectively). Soft drinks were available in 68.5% of the vending sites selling beverages. Homemade and industrial street foods, with heterogeneous nutritional value, were widely available in Dushanbe. Policies promoting the availability of healthy foods should be encouraged.</summary>
    <dc:date>2019-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>A Cross-Sectional Study of the Street Foods Purchased by Customers in Urban Areas of Central Asia</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/137513" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/137513</id>
    <updated>2026-03-17T07:45:05Z</updated>
    <published>2021-01-01T00:00:00Z</published>
    <summary type="text">Title: A Cross-Sectional Study of the Street Foods Purchased by Customers in Urban Areas of Central Asia
Abstract: This study aimed to describe street food purchases in cities from Central Asia, considering customers' characteristics and the nutritional composition of the foods and beverages. Cross-sectional studies were conducted in 2016/2017 in Dushanbe (Tajikistan), Bishkek (Kyrgyzstan), Ashgabat (Turkmenistan) and Almaty (Kazakhstan). Direct observation was used to collect data on the purchases made by street food customers, selected by random and systematic sampling. Nutritional composition was estimated using data from chemical analyses, food composition tables or food labels. A total of 714 customers (56.6% females, 55.5% aged &amp; GE;35 years, 23.3% overweight/obese) were observed, who bought 852 foods and beverages, the most frequent being savoury pastries/snacks (23.2%), main dishes (19.0%), sweet pastries/confectionery (17.9%), tea/coffee (11.3%) and soft drinks/juices (9.8%). Fruit was the least purchased food (1.1%). Nearly one-third of customers purchased industrial food items (31.9%). The median energy content of a street food purchase was 529 kcal/serving. Saturated and trans-fat median contents were 4.7 g/serving and 0.36 g/serving (21.4% and 16.5% of maximum daily intake recommendations, respectively). Median sodium and potassium contents were 745 mg/serving (37.3% of maximum recommendation) and 304 mg/serving (8.7% of minimum recommendation), respectively. In general, the purchases observed presented high contents of energy, saturated-fat, trans-fat and sodium, and low levels of potassium. Policies towards the improvement of these urban food environments should be encouraged.&lt;/p&gt;</summary>
    <dc:date>2021-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer Activity by Applying the Heavy-Atom Effect</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/146883" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/146883</id>
    <updated>2026-03-16T07:46:04Z</updated>
    <published>2021-01-01T00:00:00Z</published>
    <summary type="text">Title: Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer Activity by Applying the Heavy-Atom Effect
Abstract: Photodynamic therapy (PDT) is an anticancer therapeutic modality with remarkable advantages over more conventional approaches. However, PDT is greatly limited by its dependence on external light sources. Given this, PDT would benefit from new systems capable of a light-free and intracellular photodynamic effect. Herein, we evaluated the heavy-atom effect as a strategy to provide anticancer activity to derivatives of coelenterazine, a chemiluminescent single-molecule widespread in marine organisms. Our results indicate that the use of the heavy-atom effect allows these molecules to generate readily available triplet states in a chemiluminescent reaction triggered by a cancer marker. Cytotoxicity assays in different cancer cell lines showed a heavy-atom-dependent anticancer activity, which increased in the substituent order of hydroxyl &lt; chlorine &lt; bromine. Furthermore, it was found that the magnitude of this anticancer activity is also dependent on the tumor type, being more relevant toward breast and prostate cancer. The compounds also showed moderate activity toward neuroblastoma, while showing limited activity toward colon cancer. In conclusion, the present results indicate that the application of the heavy-atom effect to marine coelenterazine could be a promising approach for the future development of new and optimized self-activating and tumor-selective sensitizers for light-free PDT.</summary>
    <dc:date>2021-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Lessons from Four Decades of Systemic Amyloidosis with Renal Involvement</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/147529" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/147529</id>
    <updated>2026-03-16T07:40:46Z</updated>
    <published>2023-01-01T00:00:00Z</published>
    <summary type="text">Title: Lessons from Four Decades of Systemic Amyloidosis with Renal Involvement
Abstract: Background: Apart from ATTR amyloidosis, the epidemiology and outcomes of the most common subtypes of systemic amyloidosis in Portugal remain primarily unknown. Methods: This retrospective cohort study evaluated patients with renal biopsy-proven amyloidosis, diagnosed from January 1978 to December 2019. Follow-up started at kidney disease presentation and ended at death or August 2020. Clinical presentation, survival, and prognostic factors were analysed. Results: Of 123 patients with amyloid nephropathy, 111 had definite amyloid typing and were analysed. AA amyloidosis was the most frequent type (56.1%) and was related mainly to chronic infection (47.8%) and chronic inflammatory arthritis (29.0%). AL amyloidosis was present in 25.2% of patients and hereditary forms in 6.5% (4.1% AFibE526V, 2.4% ATTRV30M). During follow-up, 73.9% of AA and 54.8% of AL patients progressed to end-stage renal disease, and 79.7% of AA and 77.4% of AL died; median overall survival was 66.0 (95% CI, 33.0-99.0) and 18.0 (95% CI, 9.3-26.7) months (p = 0.025), respectively. There were no significant differences in renal outcome and survival on dialysis between these two types. In multivariate analysis, cardiac involvement at presentation (HR 6.26 [95% CI, 2.89-13.56]) and estimated glomerular filtration rate &lt;30 mL/min/1.73 m(2) (HR 2.05 [95% CI, 1.06-3.99]) independently influenced AA and AL amyloidosis survival. Cardiac involvement at presentation was an independent predictor of death (HR 9.65 [95% CI, 2.91-31.95]) and early mortality in AL amyloidosis. Conclusions: In Portugal, AA amyloidosis and related chronic infections are still relevant. Regarding AL amyloidosis, the low incidence and advanced disease at presentation result from missed and erroneous diagnoses, leading to delayed referrals and poor outcomes in these patients.</summary>
    <dc:date>2023-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Interventions to Reduce Sodium Consumption Through a Reduction in Salt Usage in Cooking-A Systematic Review and Meta-analysis</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/171897" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/171897</id>
    <updated>2026-01-31T07:32:54Z</updated>
    <published>2025-01-01T00:00:00Z</published>
    <summary type="text">Title: Interventions to Reduce Sodium Consumption Through a Reduction in Salt Usage in Cooking-A Systematic Review and Meta-analysis
Abstract: Context: Public health experts have identified salt as a primary dietary risk factor, leading many countries worldwide, recognizing its cost-effectiveness, to implement salt-reduction programs to combat cardiovascular disease and other chronic illnesses. Some nations found that a substantial portion of dietary salt comes from cooking practices. Objectives: This systematic review aims to describe and assess the effectiveness of interventions aimed at decreasing salt usage in cooking. Data Sources: A search across Scopus, PubMed, and Web of Science was conducted to identify interventions from the past decade that target reduced salt usage during cooking, with effectiveness measured through 24-hour urinary sodium excretion. Data Extraction: Thirteen studies were ultimately included (comprising 5 intervention study protocols and 8 randomized controlled trials). Data Analysis: The interventions primarily focused on adult participants (n = 11). The interventions ranged from educational initiatives, education combined with salt-restricted utensils, warning labels on salt containers, substitution of salt with potassium-enriched low-sodium alternatives to the use of dosing devices for cooking at home. While 3 studies reported a significant reduction in urinary sodium excretion (mainly through educational efforts), others showed decreases without statistically significant differences between groups. The performed meta-analysis with data from 3185 participants indicated that interventions to reduce salt usage during cooking showed a significant trend towards reducing sodium intake (Hedges' g, -1.06; 95% CI, -1.68 to -0.44; P &lt; .001). Conclusion: The findings suggest that interventions targeting reduced salt usage are effective on sodium intake reduction, assessed by 24-hour urinary sodium excretion, particularly among hypertensive individuals. This approach could aid in achieving the World Health Organization's goal of a 30% reduction in salt intake by 2030.</summary>
    <dc:date>2025-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>The Relevance of Plant-Based Diets and Micronutrient Supplementation for Body Composition: Data from the VeggieNutri Cross-Sectional Study</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/163793" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/163793</id>
    <updated>2026-01-28T07:04:50Z</updated>
    <published>2024-01-01T00:00:00Z</published>
    <summary type="text">Title: The Relevance of Plant-Based Diets and Micronutrient Supplementation for Body Composition: Data from the VeggieNutri Cross-Sectional Study
Abstract: Objectives: This study aimed to compare the anthropometry and body composition of vegetarian and omnivorous adults living in Portugal, while exploring nutritional and health parameters underlying observed differences. Methods: 425 omnivorous (OMNI), lacto-ovo-vegetarian (LOV), or vegan (VEG) healthy adults were recruited. Anthropometry was measured, and bioelectrical impedance analysis was performed. Participants answered food frequency, sociodemographic, and lifestyle questionnaires. Serum iron, ferritin, and CRP were quantified by spectrophotometry, and serum B12 vitamin and homocysteine were quantified by chemiluminescent microparticle immunoassay. Results: Total protein intake significantly decreased with increasing strictness of vegetarian habits (median (P25; P75) in g/day: 98.6 (79.5; 123.1), 90.4 (65.9; 121.0), and 87.6 (59.8; 118.5) for OMNI, LOV and VEG, respectively; p = 0.020), and carbohydrate intake was the highest in LOV (median (P25; P75) in g/day: 231.5 (178.4; 287.9), 283.9 (227.3; 342.6), and 263.0 (222.0; 348.3) for OMNI, LOV and VEG, respectively; p = 0.001). VEG were the main users of B12 vitamin (93% in VEG vs. 17% in OMNI and 59% in LOV, p = 0.001), and LOV were the main users of iron supplements (29% in LOV vs. 14% in OMNI and 13% in VEG, p = 0.042), respectively. Blood levels of B12 vitamin correlated negatively with blood homocysteine (r(s) = -0.386, p &lt; 0.001) and positively with % muscle mass (r(s) = 0.136, p = 0.005). Participants using iron supplements presented higher C-reactive protein (CRP) (p = 0.014) and they had lower % MM (p = 0.003). Finally, when compared to being OMNI, being LOV independently associated with: (a) having +4.8% (p = 0.002) of fat mass, which could be due to higher carbohydrate intake, and (b) having -2.2% (p = 0.043) of muscle mass. Our data suggest that the association between diet and muscle mass could be attenuated in VEG due to B12 supplementation and/or aggravated in LOV due to iron supplementation-associated inflammation.</summary>
    <dc:date>2024-01-01T00:00:00Z</dc:date>
  </entry>
  <entry>
    <title>Why, how and when are patients with Chromosomal anomalies hospitalized?</title>
    <link rel="alternate" href="https://hdl.handle.net/10216/172307" />
    <author>
      <name />
    </author>
    <id>https://hdl.handle.net/10216/172307</id>
    <updated>2026-01-21T07:34:36Z</updated>
    <published>2017-01-01T00:00:00Z</published>
    <summary type="text">Title: Why, how and when are patients with Chromosomal anomalies hospitalized?</summary>
    <dc:date>2017-01-01T00:00:00Z</dc:date>
  </entry>
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